Tag | Content |
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CPLM ID | CPLM-008549 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 |
Protein Synonyms/Alias | Glucosaminyl N-deacetylase/N-sulfotransferase 2; NDST-2; N-heparan sulfate sulfotransferase 2; N-HSST 2; Heparan sulfate N-deacetylase 2; Heparan sulfate N-sulfotransferase 2 |
Gene Name | NDST2 |
Gene Synonyms/Alias | HSST2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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588 | WQNPCDDKRHKDIWS | acetylation | [1] | 591 | PCDDKRHKDIWSKEK | acetylation | [1] |
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Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. |
Sequence Annotation | NP_BIND 613 617 PAPS (By similarity). NP_BIND 832 836 PAPS (By similarity). REGION 41 597 Heparan sulfate N-deacetylase 2. REGION 598 883 Heparan sulfate N-sulfotransferase 2. ACT_SITE 613 613 For sulfotransferase activity (By BINDING 711 711 PAPS (By similarity). CARBOHYD 233 233 N-linked (GlcNAc...) (Potential). CARBOHYD 350 350 N-linked (GlcNAc...) (Potential). CARBOHYD 400 400 N-linked (GlcNAc...) (Potential). CARBOHYD 666 666 N-linked (GlcNAc...) (Potential). CARBOHYD 726 726 N-linked (GlcNAc...) (Potential). CARBOHYD 802 802 N-linked (GlcNAc...) (Potential). DISULFID 817 827 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Golgi apparatus; Hydrolase; Membrane; Multifunctional enzyme; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 883 AA |
Protein Sequence | MLQLWKVVRP ARQLELHRLI LLLIAFSLGS MGFLAYYVST SPKAKEPLPL PLGDCSSGGA 60 AGPGPARPPV PPRPPRPPET ARTEPVVLVF VESAYSQLGQ EIVAILESSR FRYSTELAPG 120 RGDMPTLTDN THGRYVLVIY ENLLKYVNLD AWSRELLDRY CVEYGVGIIG FFRAHEHSLL 180 SAQLKGFPLF LHSNLGLRDY QVNPSAPLLH LTRPSRLEPG PLPGDDWTIF QSNHSTYEPV 240 LLASLRPAEP AVPGPVLRRA RLPTVVQDLG LHDGIQRVLF GHGLSFWLHK LIFVDAVAYL 300 TGKRLCLDLD RYILVDIDDI FVGKEGTRMK VADVEALLTT QNKLRTLVPN FTFNLGFSGK 360 FYHTGTEEED AGDDMLLKHR KEFWWFPHMW SHMQPHLFHN RSVLADQMRL NKQFALEHGI 420 PTDLGYAVAP HHSGVYPIHT QLYEAWKSVW GIQVTSTEEY PHLRPARYRR GFIHNGIMVL 480 PRQTCGLFTH TIFYNEYPGG SRELDRSIRG GELFLTVLLN PISIFMTHLS NYGNDRLGLY 540 TFESLVRFLQ CWTRLRLQTL PPVPLAQKYF ELFPQERSPL WQNPCDDKRH KDIWSKEKTC 600 DRLPKFLIVG PQKTGTTAIH FFLSLHPAVT SSFPSPSTFE EIQFFNSPNY HKGIDWYMDF 660 FPVPSNASTD FLFEKSATYF DSEVVPRRGA ALLPRAKIIT VLTNPADRAY SWYQHQRAHG 720 DPVALNYTFY QVISASSQTP LALRSLQNRC LVPGYYSTHL QRWLTYYPSG QLLIVDGQEL 780 RTNPAASMES IQKFLGITPF LNYTRTLRFD DDKGFWCQGL EGGKTRCLGR SKGRRYPDMD 840 TESRLFLTDF FRNHNLELSK LLSRLGQPVP SWLREELQHS SLG 883 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; TAS:ProtInc. GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:EC. GO:0019213; F:deacetylase activity; IEA:Compara. GO:0005975; P:carbohydrate metabolic process; TAS:Reactome. GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome. GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway. GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway. GO:0002002; P:regulation of angiotensin levels in blood; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
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