UniProt Accession

 ALG2_HUMAN; Q9H553; A2A2Y0; Q8NBX2; Q8NC39 

Genbank Protein ID

 AB161356; AY358697; AK027417; AK074704; AK074988; AK075172; AL137067; BC017876 

Genbank Nucleotide ID

 BAD11905.1; AAQ89060.1; BAB55099.1; BAC11150.1; BAC11337.1; BAC11449.1; CAC07999.1; AAH17876.1 

Protein Name

 Alpha-1,3/1,6-mannosyltransferase ALG2 

Protein Synonyms/Alias

 Asparagine-linked glycosylation protein 2 homolog; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase 

Gene Name

 ALG2 

Gene Synonyms/Alias

 UNQ666/PRO1298 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	QARGCSVKIWTAHYD	ubiquitination	[1]
146	FPDLLLTKRDSFLKR	ubiquitination	[1]
152	TKRDSFLKRLYRAPI	ubiquitination	[1]
285	VEHYQELKKMVQQSD	ubiquitination	[2]
286	EHYQELKKMVQQSDL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Congenital disorder of glycosylation; Glycosyltransferase; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0000033; F:alpha-1,3-mannosyltransferase activity; IDA:UniProtKB.
 GO:0048306; F:calcium-dependent protein binding; IMP:UniProtKB.
 GO:0004378; F:GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; IEA:EC.
 GO:0033164; F:glycolipid 6-alpha-mannosyltransferase activity; IEA:InterPro.
 GO:0043495; F:protein anchor; IMP:UniProtKB.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IGI:UniProtKB.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0033577; P:protein glycosylation in endoplasmic reticulum; IGI:UniProtKB.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0051592; P:response to calcium ion; IDA:UniProtKB. 

Interpro

 IPR027054; ALG2.
 IPR001296; Glyco_trans_1. 

Pfam

 PF00534; Glycos_transf_1 

SMART

  

PROSITE

  

PRINTS