CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Bop 
Protein Synonyms/Alias
 BH3-only protein 
Gene Name
 BOP 
Gene Synonyms/Alias
 C22orf29 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65VRTTMEQKSTASGTCubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity. 
Sequence Annotation
 MOTIF 114 128 BH3.  
Keyword
 Apoptosis; Complete proteome; Mitochondrion; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP CCGDTVCVRT 60
TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP GSDPGTFDGS PWLLDRFLAQ 120
LGDYMSFHFE HYQDNISRVC EILRRLTGRA QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ 180
DPNSFAEYHA VVTCPLPLAS SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT 240
PAVSGSNSVS RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV 300
PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE APETPGEPPL 360
SPGF 364 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0097345; P:mitochondrial outer membrane permeabilization; IMP:UniProtKB.
 GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS01259; BH3 
PRINTS