UniProt Accession

 ELF1_HUMAN; P32519; B4E2I5; E9PDQ9; Q8N6F6; Q9UDE1 

Genbank Protein ID

 M82882; AK304289; AL157877; CH471075; BC030507 

Genbank Nucleotide ID

 BAG65147.1; CAI13220.1; EAX08640.1; AAH30507.1 

Protein Name

 ETS-related transcription factor Elf-1 

Protein Synonyms/Alias

 E74-like factor 1 

Gene Name

 ELF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
229	ATCPKYIKWTQREKG	ubiquitination	[1]
239	QREKGIFKLVDSKAV	ubiquitination	[1]
244	IFKLVDSKAVSRLWG	ubiquitination	[1, 2]
256	LWGKHKNKPDMNYET	ubiquitination	[1]
279	YQRGILAKVEGQRLV	ubiquitination	[1]
290	QRLVYQFKEMPKDLI	ubiquitination	[1, 2, 3]
346	GGATTVLKPGNSKAA	acetylation	[2]
354	PGNSKAAKPKDPVEV	ubiquitination	[1]
481	SQPMTVLKENVMLQS	ubiquitination	[1]
571	TLTQEVEKKESEDHL	ubiquitination	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

 Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. 

Sequence Annotation

 DNA_BIND 208 290 ETS.
 MOD_RES 163 163 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 432 432 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 619 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0001817; P:regulation of cytokine production; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR022084; TF_Elf_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF12310; Elf-1_N
 PF00178; Ets 

SMART

 SM00413; ETS 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 

PRINTS

 PR00454; ETSDOMAIN.