UniProt Accession

 CPZIP_HUMAN; Q6JBY9; B1AK48; Q4G0E7; Q6IN93; Q8IZM2; Q96DX0; Q9NST4 

Genbank Protein ID

 AY530954; AF545852; CH471067; AL031733; AL356532; AL356532; AL031733; BC072399; BC098426; BC101536; BC101562; BC013186; AL137762 

Genbank Nucleotide ID

 AAS99235.1; AAN52359.1; EAW90797.1; CAI21377.1; CAI21377.1; CAI21595.1; CAI21595.1; AAH72399.1; AAH98426.1; AAI01537.1; AAI01563.1; AAH13186.1; CAB70910.1 

Protein Name

 CapZ-interacting protein 

Protein Synonyms/Alias

 Protein kinase substrate CapZIP; RCSD domain-containing protein 1 

Gene Name

 RCSD1 

Gene Synonyms/Alias

 CAPZIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	HPPKFKVKSSPLIEK	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. 

Sequence Annotation

 DOMAIN 227 330 RCSD.
 MOD_RES 68 68 Phosphoserine; by MAPK8; in vitro.
 MOD_RES 83 83 Phosphoserine; by MAPK8; in vitro.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 108 108 Phosphoserine; by MAPK12 and MAPK13.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 123 123 Phosphoserine.
 MOD_RES 124 124 Phosphothreonine.
 MOD_RES 127 127 Phosphoserine.
 MOD_RES 177 177 Phosphoserine.
 MOD_RES 179 179 Phosphoserine; by MAPKAPK2 and MAPKAPK3.
 MOD_RES 216 216 Phosphoserine; by MAPK8; in vitro.
 MOD_RES 244 244 Phosphoserine; by MAPKAPK2 or MAPKAPK3;
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 268 268 Phosphoserine.
 MOD_RES 284 284 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IC:BHF-UCL.
 GO:0071474; P:cellular hyperosmotic response; IDA:BHF-UCL.
 GO:0003009; P:skeletal muscle contraction; ISS:BHF-UCL. 

Interpro

 IPR007850; RCSD. 

Pfam

 PF05177; RCSD 

SMART

  

PROSITE

  

PRINTS