CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020725
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoglucomutase-1 
Protein Synonyms/Alias
 PGM 1; Glucose phosphomutase 1; Phosphoglucomutase-2 
Gene Name
 Pgm1 
Gene Synonyms/Alias
 Pgm2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
8MVKIVTVKTQAYPDQacetylation[1]
8MVKIVTVKTQAYPDQubiquitination[2]
16TQAYPDQKPGTSGLRacetylation[3, 4]
16TQAYPDQKPGTSGLRubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 
Functional Description
 This enzyme participates in both the breakdown and synthesis of glucose (By similarity). 
Sequence Annotation
 ACT_SITE 117 117 Phosphoserine intermediate (By
 METAL 117 117 Magnesium; via phosphate group (By
 METAL 288 288 Magnesium (By similarity).
 METAL 290 290 Magnesium (By similarity).
 METAL 292 292 Magnesium (By similarity).
 MOD_RES 16 16 N6-acetyllysine (By similarity).
 MOD_RES 115 115 Phosphothreonine.
 MOD_RES 117 117 Phosphoserine.
 MOD_RES 353 353 Phosphotyrosine.
 MOD_RES 467 467 Phosphothreonine; by PAK1 (By  
Keyword
 Acetylation; Carbohydrate metabolism; Complete proteome; Cytoplasm; Glucose metabolism; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 562 AA 
Protein Sequence
MVKIVTVKTQ AYPDQKPGTS GLRKRVKVFQ SNANYAENFI QSIVSTVEPA LRQEATLVVG 60
GDGRFYMTEA IQLIVRIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP 120
GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAIC PDLKVDLGVL GKQQFDLENK 180
FKPFTVEIVD SVEAYATMLR NIFDFNALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE 240
LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH 300
GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVANATKI ALYETPTGWK 360
FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQSVE DILKDHWQKF 420
GRNFFTRYDY EEVEAEGANK MMKDLEALML DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV 480
DGSISKNQGL RLIFADGSRI IFRLSGTGSA GATIRLYIDS YEKDVAKINQ DPQVMLAPLI 540
SIALKVSQLQ ERTGRTAPTV IT 562 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004614; F:phosphoglucomutase activity; IDA:MGI.
 GO:0019388; P:galactose catabolic process; IBA:RefGenome.
 GO:0006006; P:glucose metabolic process; IDA:MGI.
 GO:0005978; P:glycogen biosynthetic process; IBA:RefGenome. 
Interpro
 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005846; A-D-PHexomutase_a/b/a-III.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS.
 IPR005841; Alpha-D-phosphohexomutase_SF. 
Pfam
 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF02880; PGM_PMM_III
 PF00408; PGM_PMM_IV 
SMART
  
PROSITE
 PS00710; PGM_PMM 
PRINTS
 PR00509; PGMPMM.