UniProt Accession

 E7EUI5_HUMAN; E7EUI5 

Genbank Protein ID

 AC073195; AC080162; AC092206 

Genbank Nucleotide ID

  

Protein Name

 Disintegrin and metalloproteinase domain-containing protein 17 

Protein Synonyms/Alias

  

Gene Name

 ADAM17 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
168	DKRMLVYKSEDIKNV	ubiquitination	[1]
273	SWDNAGFKGYGIQIE	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR024079; MetalloPept_cat_dom.
 IPR002870; Peptidase_M12B_N. 

Pfam

 PF01562; Pep_M12B_propep 

SMART

  

PROSITE

  

PRINTS