UniProt Accession

 GPD1_YEAST; Q00055; A5YWB0; D6VRW8; Q6J5J2; Q6J5J5 

Genbank Protein ID

 Z24454; X76859; U04621; AY598965; AY598968; Z48432; Z74071; EF596737; M38740; BK006938 

Genbank Nucleotide ID

 CAA80827.1; CAA54189.1; AAA64936.1; AAT27375.1; AAT27378.1; CAA88337.1; CAA98582.1; ABQ58864.1; AAA18631.1; DAA11828.1 

Protein Name

 Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 

Protein Synonyms/Alias

  

Gene Name

 GPD1 

Gene Synonyms/Alias

 DAR1; HOR1; OSG1; YDL022W; D2830 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
138	PRICSQLKGHVDSHV	acetylation	[1]
152	VRAISCLKGFEVGAK	acetylation	[1]
211	KDFRGEGKDVDHKVL	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells. 

Sequence Annotation

 NP_BIND 41 46 NAD (By similarity).
 REGION 310 311 Substrate binding (By similarity).
 ACT_SITE 245 245 Proton acceptor (By similarity).
 BINDING 129 129 NAD (By similarity).
 BINDING 152 152 NAD; via amide nitrogen (By similarity).
 BINDING 152 152 Substrate (By similarity).
 BINDING 185 185 NAD; via amide nitrogen (By similarity).
 BINDING 310 310 NAD (By similarity).
 BINDING 339 339 NAD (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 27 27 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Peroxisome; Phosphoprotein; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005777; C:peroxisome; IDA:SGD.
 GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IMP:SGD.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
 GO:0006973; P:intracellular accumulation of glycerol; IMP:SGD.
 GO:0006116; P:NADH oxidation; IMP:SGD. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR006168; G3P_DH_NAD-dep.
 IPR006109; G3P_DH_NAD-dep_C.
 IPR017751; G3P_DH_NAD-dep_euk.
 IPR011128; G3P_DH_NAD-dep_N.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF07479; NAD_Gly3P_dh_C
 PF01210; NAD_Gly3P_dh_N 

SMART

  

PROSITE

 PS00957; NAD_G3PDH 

PRINTS

 PR00077; GPDHDRGNASE.