| Tag | Content |
|---|
| CPLM ID | CPLM-022422 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ADP-ribosylation factor-binding protein GGA3 |
Protein Synonyms/Alias | Golgi-localized, gamma ear-containing, ARF-binding protein 3 |
Gene Name | GGA3 |
Gene Synonyms/Alias | KIAA0154 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 152 | LAKLLKSKNPDDLQE | ubiquitination | [1] | | 231 | NKRRTLFKLASETED | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. |
Sequence Annotation | DOMAIN 16 146 VHS.
DOMAIN 171 298 GAT.
DOMAIN 594 715 GAE.
REGION 1 313 Binds to ARF1 (in long isoform).
REGION 299 593 Unstructured hinge.
MOTIF 391 395 Autoinhibitory. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 723 AA |
Protein Sequence | MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW 60
EALQALTYLG DRVSEKVKTK VIELLYSWTM ALPEEAKIKD AYHMLKRQGI VQSDPPIPVD 120
RTLIPSPPPR PKNPVFDDEE KSKLLAKLLK SKNPDDLQEA NKLIKSMVKE DEARIQKVTK 180
RLHTLEEVNN NVRLLSEMLL HYSQEDSSDG DRELMKELFD QCENKRRTLF KLASETEDND 240
NSLGDILQAS DNLSRVINSY KTIIEGQVIN GEVATLTLPD SEGNSQCSNQ GTLIDLAELD 300
TTNSLSSVLA PAPTPPSSGI PILPPPPQAS GPPRSRSSSQ AEATLGPSST SNALSWLDEE 360
LLCLGLADPA PNVPPKESAG NSQWHLLQRE QSDLDFFSPR PGTAACGASD APLLQPSAPS 420
SSSSQAPLPP PFPAPVVPAS VPAPSAGSSL FSTGVAPALA PKVEPAVPGH HGLALGNSAL 480
HHLDALDQLL EEAKVTSGLV KPTTSPLIPT TTPARPLLPF STGPGSPLFQ PLSFQSQGSP 540
PKGPELSLAS IHVPLESIKP SSALPVTAYD KNGFRILFHF AKECPPGRPD VLVVVVSMLN 600
TAPLPVKSIV LQAAVPKSMK VKLQPPSGTE LSPFSPIQPP AAITQVMLLA NPLKEKVRLR 660
YKLTFALGEQ LSTEVGEVDQ FPPVEQWGNL 690 |
Gene Ontology | GO:0030131; C:clathrin adaptor complex; IEA:InterPro. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005802; C:trans-Golgi network; IDA:UniProtKB. GO:0030306; F:ADP-ribosylation factor binding; IDA:UniProtKB. GO:0006886; P:intracellular protein transport; NAS:UniProtKB. GO:0016192; P:vesicle-mediated transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |