UniProt Accession

 ARGI2_HUMAN; P78540; B2R690; Q6FHY8 

Genbank Protein ID

 D86724; U75667; U82256; AY074489; CR536550; AK312484; CH471061; BC001350; BC008464; BC029050 

Genbank Nucleotide ID

 BAA13158.1; AAB39855.1; AAC51664.1; AAL71548.1; CAG38787.1; BAG35387.1; EAW80943.1; AAH01350.1; AAH08464.1; AAH29050.1 

Protein Name

 Arginase-2, mitochondrial 

Protein Synonyms/Alias

 Kidney-type arginase; Non-hepatic arginase; Type II arginase 

Gene Name

 ARG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	IREAGLMKRLSSLGC	acetylation	[1]
78	LSFTPVPKDDLYNNL	ubiquitination	[2]
241	TFDLLIGKRQRPIHL	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. 

Sequence Annotation

 REGION 145 149 Substrate binding (By similarity).
 REGION 156 158 Substrate binding (By similarity).
 METAL 120 120 Manganese 1.
 METAL 143 143 Manganese 1.
 METAL 143 143 Manganese 2.
 METAL 145 145 Manganese 2.
 METAL 147 147 Manganese 1.
 METAL 251 251 Manganese 1.
 METAL 251 251 Manganese 2.
 METAL 253 253 Manganese 2.
 BINDING 202 202 Substrate (By similarity).
 BINDING 296 296 Substrate (By similarity).  

Keyword

 3D-structure; Arginine metabolism; Complete proteome; Hydrolase; Manganese; Metal-binding; Mitochondrion; Polymorphism; Reference proteome; Transit peptide; Urea cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004053; F:arginase activity; EXP:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
 GO:0006809; P:nitric oxide biosynthetic process; TAS:ProtInc.
 GO:0006941; P:striated muscle contraction; IEA:Compara.
 GO:0000050; P:urea cycle; TAS:Reactome.
 GO:0001657; P:ureteric bud development; IEA:Compara. 

Interpro

 IPR014033; Arginase.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 

Pfam

 PF00491; Arginase 

SMART

  

PROSITE

 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 

PRINTS

 PR00116; ARGINASE.