| Tag | Content |
|---|
| CPLM ID | CPLM-021149 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Junctophilin-2 |
Protein Synonyms/Alias | JP-2; Junctophilin type 2 |
Gene Name | Jph2 |
Gene Synonyms/Alias | Jp2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 83 | TKGRWLYKGEWTHGF | ubiquitination | [1] | | 91 | GEWTHGFKGRYGIRQ | ubiquitination | [1] | | 391 | RTSHAKAKAEAAEQA | ubiquitination | [1] | | 414 | NIARTLAKELAPDFY | ubiquitination | [1] | | 429 | QPGPEYQKRRLLQEI | ubiquitination | [1] | | 618 | PRSPVPAKQATLEPK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. |
Sequence Annotation | REPEAT 14 36 MORN 1.
REPEAT 38 59 MORN 2.
REPEAT 60 79 MORN 3.
REPEAT 82 104 MORN 4.
REPEAT 106 128 MORN 5.
REPEAT 129 151 MORN 6.
REPEAT 285 307 MORN 7.
REPEAT 308 330 MORN 8.
MOD_RES 165 165 Phosphoserine (By similarity).
MOD_RES 462 462 Phosphoserine (By similarity).
MOD_RES 479 479 Phosphoserine.
MOD_RES 483 483 Phosphothreonine. |
Keyword | Cell membrane; Complete proteome; Developmental protein; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Repeat; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 696 AA |
Protein Sequence | MSGGRFDFDD GGAYCGGWEG GKAHGHGLCT GPKGQGEYSG SWNFGFEVAG VYTWPSGNTF 60
EGYWSQGKRH GLGIETKGRW LYKGEWTHGF KGRYGIRQST NSGAKYEGTW NNGLQDGYGT 120
ETYADGGTYQ GQFTNGMRHG YGVRQSVPYG MAVVVRSPLR TSLSSLRSEH SNGTVAPDSP 180
AADGPMLPSP PVPRGGFALT LLATAEAARP QGLFTRGTLL GRLRRSESRT SLGSQRSRLS 240
FLKSELSSGA SDAASTGSLA EGAEGPDDAA APFDADIDAT TTETYMGEWK NDKRSGFGVS 300
ERSSGLRYEG EWLDNLRHGY GRTTLPDGHR EEGKYRHNVL VKGTKRRVLP LKSSKVRQKV 360
EHGVEGAQRA AAIARQKAEI AASRTSHAKA KAEAAEQAAL AANQESNIAR TLAKELAPDF 420
YQPGPEYQKR RLLQEILENS ESLLEPPERG LGTGLPERPR ESPQLHERET PQPEGGPPSP 480
AGTPPQPKRP RPGASKDGLL SPGSWNGEPG GEGSRPATPS DGAGRRSPAR PASEHMAIEA 540
LQPPPAPSQE PEVAMYRGYH SYAVRTGPPE PPPLEDEQEP EPEPEPEVRR SDSAPPSPVS 600
ATVPEEEPPA PRSPVPAKQA TLEPKPIVPK AEPKAKARKT EARGLSKAGA KKKGRKEVAQ 660
AKEAEVEVEE VPNTVLICMV ILLNIGLAIL FVHLLT 696 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030314; C:junctional membrane complex; IMP:UniProtKB. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016529; C:sarcoplasmic reticulum; IDA:MGI. GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0030018; C:Z disc; IDA:MGI. GO:0015278; F:calcium-release channel activity; IMP:UniProtKB. GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:MGI. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara. GO:0055024; P:regulation of cardiac muscle tissue development; IMP:UniProtKB. |
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