CPLM-005251

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-005251

UniProt Accession

Genbank Protein ID

M64730; U29579; U00096; AP009048; AF004287; AF001987; AF001988; AF001989; AF001990; AF001991; AF001992; AF001993; AF001994; AF001995; AF001996; AF001997; AF001998; AF001999; AF002000; AF002001; AF002002; AF002003; AF002004; AF002005; AF002006; AF002007; AF002008; AF002009; AF002010

Genbank Nucleotide ID

AAA24188.1; AAA69243.1; AAC75775.1; BAE76810.1; AAD01197.1; AAD00921.1; AAD00922.1; AAD00923.1; AAD00924.1; AAD00925.1; AAD00926.1; AAD00927.1; AAD00928.1; AAD00929.1; AAD00930.1; AAD00931.1; AAD00932.1; AAD00933.1; AAD00934.1; AAD00935.1; AAD00936.1; AAD00937.1; AAD00938.1; AAD00939.1; AAD00940.1; AAD00941.1; AAD00942.1; AAD00943.1; AAD00944.1

Protein Name

DNA mismatch repair protein MutS

Protein Synonyms/Alias

Gene Name

mutS

Gene Synonyms/Alias

fdv; b2733; JW2703

Created Date

July 27, 2013

Organism

Escherichia coli (strain K12)

NCBI Taxa ID

83333

Lysine Modification

Position	Peptide	Type	References
45	ELFYDDAKRASQLLD	acetylation	[1]
575	TCPTFIDKPGIRITE	acetylation	[1]
783	AALAGVPKEVIKRAR	acetylation	[1]

Reference

[1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]

Functional Description

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

Sequence Annotation

NP_BIND 614 621 ATP (Potential).

Keyword

3D-structure; ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

853 AA

Protein Sequence

MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA 60
SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS 120
DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY 180
AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL 240
LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT 300
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA 360
RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR 420
DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG 480
QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE 540
ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP 600
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA 660
DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK 720
ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG 780
VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR 840
QALEWIYRLK SLV 853

Gene Ontology

GO:0032300; C:mismatch repair complex; IGI:EcoliWiki.
GO:0032136; F:adenine/cytosine mispair binding; IDA:EcoliWiki.
GO:0043531; F:ADP binding; IDA:EcoliWiki.
GO:0005524; F:ATP binding; IDA:EcoliWiki.
GO:0003684; F:damaged DNA binding; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IDA:EcoliWiki.
GO:0008094; F:DNA-dependent ATPase activity; IBA:RefGenome.
GO:0006298; P:mismatch repair; IDA:EcoliWiki.
GO:0000018; P:regulation of DNA recombination; IMP:EcoliWiki.

Interpro

IPR005748; DNA_mismatch_repair_MutS-1.
IPR007695; DNA_mismatch_repair_MutS-lik_N.
IPR000432; DNA_mismatch_repair_MutS_C.
IPR007861; DNA_mismatch_repair_MutS_clamp.
IPR007696; DNA_mismatch_repair_MutS_core.
IPR016151; DNA_mismatch_repair_MutS_N.
IPR007860; DNA_mmatch_repair_MutS_con_dom.
IPR027417; P-loop_NTPase.

Pfam

PF01624; MutS_I
PF05188; MutS_II
PF05192; MutS_III
PF05190; MutS_IV
PF00488; MutS_V

SMART

SM00534; MUTSac
SM00533; MUTSd

PROSITE

PS00486; DNA_MISMATCH_REPAIR_2

PRINTS