CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase TRIM37 
Protein Synonyms/Alias
  
Gene Name
 TRIM37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
200HQLRSCSKSELISKSubiquitination[1]
377RSPTFFQKSRDQHWYubiquitination[1]
440ALETRAKKSACSDMLubiquitination[1]
639WRVPSDLKMLKRLKTubiquitination[1]
659RCMKTDVKNTLSEIKubiquitination[2, 3]
708LGMELLAKSSVANCYubiquitination[1]
753PGENSRSKGDCQTLSubiquitination[1]
790SIGDILPKTEDRQCKubiquitination[2]
820PAVEKRRKMVTLGANubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 930 AA 
Protein Sequence
MDEQSVERWL TEQRAQCPHC RAPLQLRELV NCRWAEEVTQ QLDTLQLCSL TKHEENEKDK 60
CENHHEKLSV FCWTCKKCIC HQCALWGGMH GGHTFKPLAE IYEQHVTKVN EEVAKLRRRL 120
MELISLVQEV ERNVEAVRNA KDERVREIRN AVEMMIARLD TQLKNKLITL MGQKTSLTQE 180
TELLESLLQE VEHQLRSCSK SELISKSSEI LMMFQQVHRK PMASFVTTPV PPDFTSELVP 240
SYDSATFVLE NFSTLRQRAD PVYSPPLQVS GLCWRLKVYP DGNGVVRGYY LSVFLELSAG 300
LPETSKYEYR VEMVHQSCND PTKNIIREFA SDFEVGECWG YNRFFRLDLL ANEGYLNPQN 360
DTVILRFQVR SPTFFQKSRD QHWYITQLEA AQTSYIQQIN NLKERLTIEL SRTQKSRDLS 420
PPDNHLSPQN DDALETRAKK SACSDMLLEG GPTTASVREA KEDEEDEEKI QNEDYHHELS 480
DGDLDLDLVY EDEVNQLDGS SSSASSTATS NTEENDIDEE TMSGENDVEY NNMELEEGEL 540
MEDAAAAGPA GSSHGYVGSS SRISRRTHLC SAATSSLLDI DPLILIHLLD LKDRSSIENL 600
WGLQPRPPAS LLQPTASYSR KDKDQRKQQA MWRVPSDLKM LKRLKTQMAE VRCMKTDVKN 660
TLSEIKSSSA ASGDMQTSLF SADQAALAAC GTENSGRLQD LGMELLAKSS VANCYIRNST 720
NKKSNSPKPA RSSVAGSLSL RRAVDPGENS RSKGDCQTLS EGSPGSSQSG SRHSSPRALI 780
HGSIGDILPK TEDRQCKALD SDAVVVAVFS GLPAVEKRRK MVTLGANAKG GHLEGLQMTD 840
LENNSETGEL QPVLPEGASA APEEGMSSDS DIECDTENEE QEEHTSVGGF HDSFMVMTQP 900
PDEDTHSSFP DGEQIGPEDL SFNTDENSGR 930 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR003649; Bbox_C.
 IPR002083; MATH.
 IPR008974; TRAF-like.
 IPR000315; Znf_B-box. 
Pfam
 PF00917; MATH
 PF00643; zf-B_box 
SMART
 SM00502; BBC
 SM00336; BBOX
 SM00061; MATH 
PROSITE
 PS50144; MATH
 PS50119; ZF_BBOX 
PRINTS