CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024367
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-density lipoprotein receptor-related protein 2 
Protein Synonyms/Alias
 LRP-2; Glycoprotein 330; gp330; Megalin 
Gene Name
 Lrp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2439NRIFFTQKLNPIRGQubiquitination[1]
4164HIYWSDAKSQRIEVAubiquitination[1]
4451VGFFHYRKTGSLLPSubiquitination[1]
4470PSLSSLAKPSENGNGubiquitination[1]
4517QFVMEVGKQPVIFENubiquitination[1]
4530ENPMYAAKDSTSKVGubiquitination[1]
4535AAKDSTSKVGLAVQGubiquitination[1]
4587ADETQGTKWNIFKRKubiquitination[1]
4648TATEDTFKDTANLVKubiquitination[1]
4655KDTANLVKEDSDV**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts together with cubilin to mediate HDL endocytosis. 
Sequence Annotation
 DOMAIN 26 64 LDL-receptor class A 1.
 DOMAIN 65 105 LDL-receptor class A 2.
 DOMAIN 106 144 LDL-receptor class A 3.
 DOMAIN 145 181 LDL-receptor class A 4.
 DOMAIN 181 219 LDL-receptor class A 5.
 DOMAIN 220 258 LDL-receptor class A 6.
 DOMAIN 263 307 LDL-receptor class A 7.
 DOMAIN 308 346 EGF-like 1.
 DOMAIN 347 385 EGF-like 2.
 REPEAT 435 477 LDL-receptor class B 1.
 REPEAT 478 520 LDL-receptor class B 2.
 REPEAT 521 567 LDL-receptor class B 3.
 REPEAT 568 611 LDL-receptor class B 4.
 REPEAT 612 652 LDL-receptor class B 5.
 DOMAIN 658 704 EGF-like 3.
 REPEAT 752 794 LDL-receptor class B 6.
 REPEAT 795 836 LDL-receptor class B 7.
 REPEAT 837 880 LDL-receptor class B 8.
 REPEAT 881 924 LDL-receptor class B 9.
 DOMAIN 969 1013 EGF-like 4.
 DOMAIN 1023 1061 LDL-receptor class A 8.
 DOMAIN 1064 1103 LDL-receptor class A 9.
 DOMAIN 1108 1146 LDL-receptor class A 10.
 DOMAIN 1148 1186 LDL-receptor class A 11.
 DOMAIN 1186 1225 LDL-receptor class A 12.
 DOMAIN 1229 1269 LDL-receptor class A 13.
 DOMAIN 1270 1308 LDL-receptor class A 14.
 DOMAIN 1311 1351 LDL-receptor class A 15.
 DOMAIN 1350 1390 EGF-like 5.
 DOMAIN 1391 1430 EGF-like 6; calcium-binding (Potential).
 REPEAT 1479 1521 LDL-receptor class B 10.
 REPEAT 1522 1564 LDL-receptor class B 11.
 REPEAT 1567 1610 LDL-receptor class B 12.
 REPEAT 1611 1654 LDL-receptor class B 13.
 REPEAT 1655 1696 LDL-receptor class B 14.
 DOMAIN 1701 1742 EGF-like 7.
 REPEAT 1791 1833 LDL-receptor class B 15.
 REPEAT 1834 1883 LDL-receptor class B 16.
 REPEAT 1884 1931 LDL-receptor class B 17.
 REPEAT 1932 1972 LDL-receptor class B 18.
 REPEAT 1973 2014 LDL-receptor class B 19.
 DOMAIN 2019 2060 EGF-like 8.
 REPEAT 2108 2157 LDL-receptor class B 20.
 REPEAT 2158 2202 LDL-receptor class B 21.
 REPEAT 2203 2246 LDL-receptor class B 22.
 REPEAT 2247 2290 LDL-receptor class B 23.
 REPEAT 2291 2332 LDL-receptor class B 24.
 DOMAIN 2343 2384 EGF-like 9.
 REPEAT 2433 2478 LDL-receptor class B 25.
 REPEAT 2479 2519 LDL-receptor class B 26.
 REPEAT 2520 2563 LDL-receptor class B 27.
 REPEAT 2564 2604 LDL-receptor class B 28.
 REPEAT 2605 2647 LDL-receptor class B 29.
 DOMAIN 2652 2694 EGF-like 10.
 DOMAIN 2699 2739 LDL-receptor class A 16.
 DOMAIN 2740 2778 LDL-receptor class A 17.
 DOMAIN 2779 2820 LDL-receptor class A 18.
 DOMAIN 2821 2862 LDL-receptor class A 19.
 DOMAIN 2863 2903 LDL-receptor class A 20.
 DOMAIN 2906 2947 LDL-receptor class A 21.
 DOMAIN 2948 2992 LDL-receptor class A 22.
 DOMAIN 2993 3031 LDL-receptor class A 23.
 DOMAIN 3032 3072 LDL-receptor class A 24.
 DOMAIN 3075 3112 LDL-receptor class A 25.
 DOMAIN 3113 3153 EGF-like 11.
 DOMAIN 3154 3194 EGF-like 12; calcium-binding (Potential).
 REPEAT 3241 3283 LDL-receptor class B 30.
 REPEAT 3284 3326 LDL-receptor class B 31.
 REPEAT 3335 3378 LDL-receptor class B 32.
 REPEAT 3379 3420 LDL-receptor class B 33.
 REPEAT 3421 3462 LDL-receptor class B 34.
 DOMAIN 3467 3511 EGF-like 13.
 DOMAIN 3512 3552 LDL-receptor class A 26.
 DOMAIN 3553 3593 LDL-receptor class A 27.
 DOMAIN 3594 3634 LDL-receptor class A 28.
 DOMAIN 3635 3675 LDL-receptor class A 29.
 DOMAIN 3678 3718 LDL-receptor class A 30.
 DOMAIN 3719 3758 LDL-receptor class A 31.
 DOMAIN 3759 3797 LDL-receptor class A 32.
 DOMAIN 3798 3836 LDL-receptor class A 33.
 DOMAIN 3842 3882 LDL-receptor class A 34.
 DOMAIN 3883 3924 LDL-receptor class A 35.
 DOMAIN 3928 3966 LDL-receptor class A 36.
 DOMAIN 3968 4008 EGF-like 14.
 DOMAIN 4009 4050 EGF-like 15; calcium-binding (Potential).
 REPEAT 4156 4198 LDL-receptor class B 35.
 REPEAT 4199 4242 LDL-receptor class B 36.
 REPEAT 4244 4285 LDL-receptor class B 37.
 DOMAIN 4332 4370 EGF-like 16.
 DOMAIN 4379 4413 EGF-like 17.
 REGION 4597 4610 Interaction with DAB2 (By similarity).
 MOTIF 1743 1745 Cell attachment site (Potential).
 MOTIF 4454 4463 SH3-binding (Potential).
 MOTIF 4522 4527 Endocytosis signal (Potential).
 MOTIF 4601 4606 NPXY motif.
 MOTIF 4606 4609 SH2-binding (Potential).
 MOTIF 4619 4630 SH3-binding (Potential).
 METAL 1206 1206 Calcium; via carbonyl oxygen (By
 METAL 1209 1209 Calcium (By similarity).
 METAL 1211 1211 Calcium; via carbonyl oxygen (By
 METAL 1213 1213 Calcium (By similarity).
 METAL 1219 1219 Calcium (By similarity).
 METAL 1220 1220 Calcium (By similarity).
 MOD_RES 4464 4464 Phosphoserine.
 MOD_RES 4472 4472 Phosphoserine.
 CARBOHYD 159 159 N-linked (GlcNAc...) (Potential).
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
 CARBOHYD 340 340 N-linked (GlcNAc...) (Potential).
 CARBOHYD 387 387 N-linked (GlcNAc...).
 CARBOHYD 399 399 N-linked (GlcNAc...); atypical.
 CARBOHYD 462 462 N-linked (GlcNAc...) (Potential).
 CARBOHYD 657 657 N-linked (GlcNAc...) (Potential).
 CARBOHYD 865 865 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1063 1063 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1187 1187 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1328 1328 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1341 1341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1384 1384 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1451 1451 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1497 1497 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1551 1551 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1676 1676 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1733 1733 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1811 1811 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2131 2131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2134 2134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2178 2178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2225 2225 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2396 2396 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2488 2488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2548 2548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2782 2782 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2810 2810 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2949 2949 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2989 2989 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3127 3127 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3213 3213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3259 3259 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3317 3317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3357 3357 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3448 3448 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3566 3566 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3682 3682 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3840 3840 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3969 3969 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3980 3980 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4070 4070 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4329 4329 N-linked (GlcNAc...) (Potential).
 DISULFID 28 40 By similarity.
 DISULFID 35 53 By similarity.
 DISULFID 47 62 By similarity.
 DISULFID 67 80 By similarity.
 DISULFID 74 93 By similarity.
 DISULFID 87 103 By similarity.
 DISULFID 108 120 By similarity.
 DISULFID 115 133 By similarity.
 DISULFID 127 142 By similarity.
 DISULFID 147 157 By similarity.
 DISULFID 152 170 By similarity.
 DISULFID 164 179 By similarity.
 DISULFID 183 195 By similarity.
 DISULFID 190 208 By similarity.
 DISULFID 202 217 By similarity.
 DISULFID 222 234 By similarity.
 DISULFID 229 247 By similarity.
 DISULFID 241 256 By similarity.
 DISULFID 265 278 By similarity.
 DISULFID 272 291 By similarity.
 DISULFID 285 306 By similarity.
 DISULFID 311 320 By similarity.
 DISULFID 316 329 By similarity.
 DISULFID 331 345 By similarity.
 DISULFID 351 361 By similarity.
 DISULFID 357 370 By similarity.
 DISULFID 372 384 By similarity.
 DISULFID 662 673 By similarity.
 DISULFID 669 688 By similarity.
 DISULFID 690 703 By similarity.
 DISULFID 973 987 By similarity.
 DISULFID 983 997 By similarity.
 DISULFID 999 1012 By similarity.
 DISULFID 1025 1037 By similarity.
 DISULFID 1032 1050 By similarity.
 DISULFID 1044 1059 By similarity.
 DISULFID 1066 1079 By similarity.
 DISULFID 1073 1092 By similarity.
 DISULFID 1086 1101 By similarity.
 DISULFID 1110 1122 By similarity.
 DISULFID 1117 1135 By similarity.
 DISULFID 1129 1144 By similarity.
 DISULFID 1150 1162 By similarity.
 DISULFID 1157 1175 By similarity.
 DISULFID 1169 1184 By similarity.
 DISULFID 1188 1201 By similarity.
 DISULFID 1195 1214 By similarity.
 DISULFID 1208 1223 By similarity.
 DISULFID 1231 1244 By similarity.
 DISULFID 1238 1257 By similarity.
 DISULFID 1251 1267 By similarity.
 DISULFID 1272 1284 By similarity.
 DISULFID 1279 1297 By similarity.
 DISULFID 1291 1306 By similarity.
 DISULFID 1313 1326 By similarity.
 DISULFID 1320 1339 By similarity.
 DISULFID 1333 1349 By similarity.
 DISULFID 1354 1365 By similarity.
 DISULFID 1361 1374 By similarity.
 DISULFID 1376 1389 By similarity.
 DISULFID 1395 1405 By similarity.
 DISULFID 1401 1414 By similarity.
 DISULFID 1416 1429 By similarity.
 DISULFID 1705 1714 By similarity.
 DISULFID 1710 1726 By similarity.
 DISULFID 1728 1741 By similarity.
 DISULFID 2023 2034 By similarity.
 DISULFID 2030 2044 By similarity.
 DISULFID 2046 2059 By similarity.
 DISULFID 2347 2358 By similarity.
 DISULFID 2354 2369 By similarity.
 DISULFID 2371 2383 By similarity.
 DISULFID 2656 2667 By similarity.
 DISULFID 2663 2676 By similarity.
 DISULFID 2678 2693 By similarity.
 DISULFID 2701 2713 By similarity.
 DISULFID 2708 2726 By similarity.
 DISULFID 2720 2737 By similarity.
 DISULFID 2742 2754 By similarity.
 DISULFID 2749 2767 By similarity.
 DISULFID 2761 2776 By similarity.
 DISULFID 2781 2794 By similarity.
 DISULFID 2789 2807 By similarity.
 DISULFID 2801 2818 By similarity.
 DISULFID 2823 2836 By similarity.
 DISULFID 2830 2849 By similarity.
 DISULFID 2843 2860 By similarity.
 DISULFID 2865 2878 By similarity.
 DISULFID 2872 2891 By similarity.
 DISULFID 2885 2901 By similarity.
 DISULFID 2908 2920 By similarity.
 DISULFID 2915 2933 By similarity.
 DISULFID 2927 2945 By similarity.
 DISULFID 2950 2967 By similarity.
 DISULFID 2957 2980 By similarity.
 DISULFID 2974 2990 By similarity.
 DISULFID 2995 3007 By similarity.
 DISULFID 3002 3020 By similarity.
 DISULFID 3014 3029 By similarity.
 DISULFID 3034 3046 By similarity.
 DISULFID 3041 3059 By similarity.
 DISULFID 3053 3070 By similarity.
 DISULFID 3077 3089 By similarity.
 DISULFID 3084 3102 By similarity.
 DISULFID 3096 3111 By similarity.
 DISULFID 3116 3128 By similarity.
 DISULFID 3124 3137 By similarity.
 DISULFID 3139 3152 By similarity.
 DISULFID 3158 3169 By similarity.
 DISULFID 3165 3178 By similarity.
 DISULFID 3180 3193 By similarity.
 DISULFID 3471 3482 By similarity.
 DISULFID 3478 3493 By similarity.
 DISULFID 3495 3510 By similarity.
 DISULFID 3514 3527 By similarity.
 DISULFID 3521 3540 By similarity.
 DISULFID 3534 3550 By similarity.
 DISULFID 3555 3567 By similarity.
 DISULFID 3562 3580 By similarity.
 DISULFID 3574 3591 By similarity.
 DISULFID 3596 3608 By similarity.
 DISULFID 3603 3621 By similarity.
 DISULFID 3615 3632 By similarity.
 DISULFID 3637 3649 By similarity.
 DISULFID 3644 3662 By similarity.
 DISULFID 3656 3673 By similarity.
 DISULFID 3680 3694 By similarity.
 DISULFID 3688 3707 By similarity.
 DISULFID 3701 3716 By similarity.
 DISULFID 3721 3734 By similarity.
 DISULFID 3729 3747 By similarity.
 DISULFID 3741 3756 By similarity.
 DISULFID 3761 3773 By similarity.
 DISULFID 3768 3786 By similarity.
 DISULFID 3780 3795 By similarity.
 DISULFID 3800 3812 By similarity.
 DISULFID 3807 3825 By similarity.
 DISULFID 3819 3834 By similarity.
 DISULFID 3844 3856 By similarity.
 DISULFID 3851 3869 By similarity.
 DISULFID 3863 3880 By similarity.
 DISULFID 3885 3898 By similarity.
 DISULFID 3893 3911 By similarity.
 DISULFID 3905 3922 By similarity.
 DISULFID 3930 3942 By similarity.
 DISULFID 3937 3955 By similarity.
 DISULFID 3949 3964 By similarity.
 DISULFID 3972 3981 By similarity.
 DISULFID 3977 3991 By similarity.
 DISULFID 3993 4007 By similarity.
 DISULFID 4013 4023 By similarity.
 DISULFID 4019 4032 By similarity.
 DISULFID 4034 4049 By similarity.
 DISULFID 4336 4344 By similarity.
 DISULFID 4340 4353 By similarity.
 DISULFID 4355 4369 By similarity.
 DISULFID 4383 4391 By similarity.
 DISULFID 4385 4401 By similarity.
 DISULFID 4403 4412 By similarity.  
Keyword
 Calcium; Coated pit; Complete proteome; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4660 AA 
Protein Sequence
MERGAAAAAW MLLLAIAACL APVSGQECGS GNFRCDNGYC IPASWRCDGT RDCLDDTDEI 60
GCPPRSCGSG FFLCPAEGTC IPSSWVCDQD KDCSDGADEQ QNCPGTTCSS QQLTCSNGQC 120
VPIEYRCDHV SDCPDGSDER NCYYPTCDQL TCANGACYNT SQKCDHKVDC RDSSDEANCT 180
TLCSQKEFQC GSGECILRAY VCDHDNDCED NSDEHNCNYD TCGGHQFTCS NGQCINQNWV 240
CDGDDDCQDS GDEDGCESNQ RHHTCYPREW ACPGSGRCIS MDKVCDGVPD CPEGEDENNA 300
TSGRYCGTGL CSILNCEYQC HQTPYGGECF CPPGHIINSN DSRTCIDFDD CQIWGICDQK 360
CESRQGRHQC LCEEGYILER GQHCKSNDSF SAASIIFSNG RDLLVGDLHG RNFRILAESK 420
NRGIVMGVDF HYQKHRVFWT DPMQAKVFST DINGLNTQEI LNVSIDAPEN LAVDWINNKL 480
YLVETRVNRI DVVNLEGNQR VTLITENLGH PRGIALDPTV GYLFFSDWGS LSGQPKVERA 540
FMDGSNRKDL VTTKLGWPAG ITLDLVSKRV YWVDSRYDYI ETVTYDGIQR KTVARGGSLV 600
PHPFGISLFE EHVFFTDWTK MAVMKANKFT DTNPQVYHQS SLTPFGVTVY HALRQPNATN 660
PCGNNNGGCA QICVLSHRTD NGGLGYRCKC EFGFELDADE HHCVAVKNFL LFSSQTAVRG 720
IPFTLSTQED VMVPVTGSPS FFVGIDFDAQ HSTIFYSDLS KNIIYQQKID GTGKEVITAN 780
RLQNVECLSF DWISRNLYWT DGGSKSVTVM KLADKSRRQI ISNLNNPRSI VVHPAAGYMF 840
LSDWFRPAKI MRAWSDGSHL MPIVNTSLGW PNGLAIDWST SRLYWVDAFF DKIEHSNLDG 900
LDRKRLGHVD QMTHPFGLTV FKDNVFLTDW RLGAIIRVRK SDGGDMTVVR RGISSIMHVK 960
AYDADLQTGT NYCSQTTHPN GDCSHFCFPV PNFQRVCGCP YGMKLQRDQM TCEGDPAREP 1020
PTQQCGSSSF PCNNGKCVPS IFRCDGVDDC HDNSDEHQCG ALNNTCSSSA FTCVHGGQCI 1080
PGQWRCDKQN DCLDGSDEQN CPTRSPSSTC PPTSFTCDNH MCIPKEWVCD TDNDCSDGSD 1140
EKNCQASGTC HPTQFRCPDH RCISPLYVCD GDKDCVDGSD EAGCVLNCTS SQFKCADGSS 1200
CINSRYRCDG VYDCKDNSDE AGCPTRPPGM CHPDEFQCQG DGTCIPNTWE CDGHPDCIQG 1260
SDEHNGCVPK TCSPSHFLCD NGNCIYNSWV CDGDNDCRDM SDEKDCPTQP FHCPSSQWQC 1320
PGYSICVNLS ALCDGVFDCP NGTDESPLCN QDSCLHFNGG CTHRCIQGPF GATCVCPIGY 1380
QLANDTKTCE DVNECDIPGF CSQHCVNMRG SFRCACDPEY TLESDGRTCK VTASENLLLV 1440
VASRDKIIMD NITAHTHNIY SLVQDVSFVV ALDFDSVTGR VFWSDLLEGK TWSAFQNGTD 1500
KRVVHDSGLS LTEMIAVDWI GRNIYWTDYT LETIEVSKID GSHRTVLISK NVTKPRGLAL 1560
DPRMGDNVMF WSDWGHHPRI ERASMDGTMR TVIVQEKIYW PCGLSIDYPN RLIYFMDAYL 1620
DYIEFCDYDG QNRRQVIASD LVLHHPHALT LFEDSVFWTD RGTHQVMQAN KWHGRNQSVV 1680
MYSVPQPLGI IAIHPSRQPS SPNPCASATC SHLCLLSAQE PRHYSCACPS GWNLSDDSVN 1740
CVRGDQPFLI SVRENVIFGI SLDPEVKSND AMVPISGIQH GYDVEFDDSE QFIYWVENPG 1800
EIHRVKTDGS NRTAFAPLSL LGSSLGLALD WVSRNIYYTT PASRSIEVLT LRGDTRYGKT 1860
LITNDGTPLG VGFPVGIAVD PARGKLYWSD HGTDSGVPAK IASANMDGTS LKILFTGNME 1920
HLEVVTLDIQ EQKLYWAVTS RGVIERGNVD GTERMILVHH LAHPWGLVVH GSFLYYSDEQ 1980
YEVIERVDKS SGSNKVVFRD NIPYLRGLRV YHHRNAADSS NGCSNNPNAC QQICLPVPGG 2040
MFSCACASGF KLSPDGRSCS PYNSFIVVSM LPAVRGFSLE LSDHSEAMVP VAGQGRNVLH 2100
ADVDVANGFI YWCDFSSSVR SSNGIRRIKP NGSNFTNIVT YGIGANGIRG VAVDWVAGNL 2160
YFTNAFVYET LIEVIRINTT YRRVLLKVSV DMPRHIVVDP KHRYLFWADY GQKPKIERSF 2220
LDCTNRTVLV SEGIVTPRGL AVDHDTGYIY WVDDSLDIIA RIHRDGGESQ VVRYGSRYPT 2280
PYGITVFGES IIWVDRNLRK VFQASKQPGN TDPPTVIRDS INLLRDVTIF DEHVQPLSPA 2340
ELNNNPCLQS NGGCSHFCFA LPELPTPKCG CAFGTLEDDG KNCATSREDF LIYSLNNSLR 2400
SLHFDPQDHN LPFQAISVEG MAIALDYDRR NNRIFFTQKL NPIRGQISYV NLYSGASSPT 2460
ILLSNIGVTD GIAFDWINRR IYYSDFSNQT INSMAEDGSN RAVIARVSKP RAIVLDPCRG 2520
YMYWTDWGTN AKIERATLGG NFRVPIVNTS LVWPNGLTLD LETDLLYWAD ASLQKIERST 2580
LTGSNREVVI STAFHSFGLT VYGQYIYWTD FYTKKIYRAN KYDGSDLIAM TTRLPTQPSG 2640
ISTVVKTQQQ QCSNPCDQFN GGCSHICAPG PNGAECQCPH EGSWYLANDN KYCVVDTGAR 2700
CNQFQFTCLN GRCISQDWKC DNDNDCGDGS DELPTVCAFH TCRSTAFTCA NGRCVPYHYR 2760
CDFYNDCGDN SDEAGCLFRS CNSTTEFTCS NGRCIPLSYV CNGINNCHDN DTSDEKNCPP 2820
ITCQPDFAKC QTTNICVPRA FLCDGDNDCG DGSDENPIYC ASHTCRSNEF QCVSPHRCIP 2880
SYWFCDGEAD CVDSSDEPDT CGHSLNSCSA NQFHCDNGRC ISSSWVCDGD NDCGDMSDED 2940
QRHHCELQNC SSTEFTCINS RPPNRRCIPQ HWVCDGDADC ADALDELQNC TMRACSTGEF 3000
SCANGRCIRQ SFRCDRRNDC GDYSDERGCS YPPCRDDQFT CQNGQCITKL YVCDEDNDCG 3060
DGSDEQEHLC HTPEPTCPPH QFRCDNGHCI EMGTVCNHVD DCSDNSDEKG CGINECQDSS 3120
ISHCDHNCTD TITSFYCSCL PGYKLMSDKR TCVDIDECKE TPQLCSQKCE NVIGSYICKC 3180
APGYIREPDG KSCRQNSNIE PYLVFSNRYY IRNLTIDGTS YSLILQGLGN VVALDFDRVE 3240
ERLYWIDAEK QIIERMFLNK TNQETIISHR LRRAESLAVD WVSRKLYWLD AILDCLFVSD 3300
LEGRQRKMLA QHCVDANNTF CFENPRGIVL HPQRGYVYWA DWGDHAYIAR IGMDGTNKTV 3360
IISTKIEWPN AITIDYTNDL LYWADAHLGY IEFSDLEGHH RHTVYDGTLP HPFALTIFED 3420
TVFWTDWNTR TVEKGNKYDG SGRVVLVNTT HKPFDIHVLH PYRQPIMSNP CATNNGGCSH 3480
LCLIKAGGRG FTCECPDDFQ TVQLRDRTLC MPMCSSTQFL CGNNEKCIPI WWKCDGQKDC 3540
SDGSDESDLC PHRFCRLGQF QCRDGNCTSP QALCNARQDC ADGSDEDRVL CEHHRCEANE 3600
WQCANKRCIP EYWQCDSVDD CLDNSDEDPS HCASRTCRPG QFKCNNGRCI PQSWKCDVDN 3660
DCGDYSDEPI HECMTAAYNC DNHTEFSCKT NYRCIPQWAV CNGFDDCRDN SDEQGCESVP 3720
CHPSGDFRCG NHHCIPLRWK CDGIDDCGDN SDEESCVPRE CTESEFRCAD QQCIPSRWVC 3780
DQENDCGDNS DERDCEMKTC HPEHFQCTSG HCVPKALACD GRADCLDASD ESACPTRFPN 3840
GTYCPAAMFE CKNHVCIQSF WICDGENDCV DGSDEEIHLC FNVPCESPQR FRCDNSRCIY 3900
GHQLCNGVDD CGDGSDEKEE HCRKPTHKPC TDTEYKCSNG NCVSQHYVCD NVDDCGDLSD 3960
ETGCNLGENR TCAEKICEQN CTQLSNGGFI CSCRPGFKPS TLDKNSCQDI NECEEFGICP 4020
QSCRNSKGSY ECFCVDGFKS MSTHYGERCA ADGSPPLLLL PENVRIRKYN ISSEKFSEYL 4080
EEEEHIQAID YDWDPEGIGL SVVYYTVLSQ GSQFGAIKRA YLPDFESGSN NPVREVDLGL 4140
KYLMQPDGLA VDWVGRHIYW SDAKSQRIEV ATLDGRYRKW LITTQLDQPA AIAVNPKLGL 4200
MFWTDQGKQP KIESAWMNGE HRSVLASANL GWPNGLSIDY LNGDRIYWSD SKEDVIESIK 4260
YDGTDRRLII NDAMKPFSLD IFEDQLYWVA KEKGEVWRQN KFGKGNKEKL LVVNPWLTQV 4320
RIFHQLRYNQ SVSNPCKQVC SHLCLLRPGG YSCACPQGSD FVTGSTVECD AASELPITMP 4380
SPCRCMHGGS CYFDENDLPK CKCSSGYSGE YCEIGLSRGI PPGTTMALLL TFAMVIIVGA 4440
LVLVGFFHYR KTGSLLPSLP KLPSLSSLAK PSENGNGVTF RSGADVNMDI GVSPFGPETI 4500
IDRSMAMNEQ FVMEVGKQPV IFENPMYAAK DSTSKVGLAV QGPSVSSQVT VPENVENQNY 4560
GRSIDPSEIV PEPKPASPGA DETQGTKWNI FKRKPKQTTN FENPIYAEMD TEQKEAVAVA 4620
PPPSPSLPAK ASKRSSTPGY TATEDTFKDT ANLVKEDSDV 4660 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0031526; C:brush border membrane; IDA:MGI.
 GO:0005905; C:coated pit; IDA:MGI.
 GO:0030139; C:endocytic vesicle; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005768; C:endosome; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004872; F:receptor activity; ISS:MGI.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0006898; P:receptor-mediated endocytosis; IMP:MGI.
 GO:0006766; P:vitamin metabolic process; IMP:MGI. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF12662; cEGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS