UniProt Accession

 ISY1_HUMAN; Q9ULR0; Q96IL2; Q9BT05 

Genbank Protein ID

 AB032986; BC004442; BC007409; BC019849 

Genbank Nucleotide ID

 BAA86474.1; AAH04442.1; AAH07409.1; AAH19849.1 

Protein Name

 Pre-mRNA-splicing factor ISY1 homolog 

Protein Synonyms/Alias

  

Gene Name

 ISY1 

Gene Synonyms/Alias

 KIAA1160 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	YKYFGAAKDLPGVRE	acetylation	[1]
259	EEALVRRKKMELLQK	glycation	[2]
260	EALVRRKKMELLQKY	glycation	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 May play a role in pre-mRNA splicing (Potential). 

Sequence Annotation

 MOD_RES 127 127 N6-acetyllysine.
 MOD_RES 247 247 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. 

Interpro

 IPR009360; Isy1. 

Pfam

 PF06246; Isy1 

SMART

  

PROSITE

  

PRINTS