UniProt Accession

 IKZF3_HUMAN; Q9UKT9; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3 

Genbank Protein ID

 AF129512; AJ292565; AJ292566; AJ292567; AJ292568; AJ292569; AY377973; AY377975; AY377976; AY377977; AY377978; AY377979; AY377980; AY377981; AY377982; CH471152; BC032707 

Genbank Nucleotide ID

 AAF13493.1; CAC80427.1; CAC80428.1; CAC80429.1; CAC80430.1; CAC80431.1; AAR84584.1; AAR84586.1; AAR84587.1; AAR84588.1; AAR84589.1; AAR84590.1; AAR84591.1; AAR84592.1; AAR84593.1; EAW60606.1; AAH32707.1 

Protein Name

 Zinc finger protein Aiolos 

Protein Synonyms/Alias

 Ikaros family zinc finger protein 3 

Gene Name

 IKZF3 

Gene Synonyms/Alias

 ZNFN1A3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	YNEYENIKLERHVVS	ubiquitination	[1, 2]
158	CGASFTQKGNLLRHI	ubiquitination	[1]
203	HSVEKPYKCEFCGRS	ubiquitination	[1, 2]
245	SAEARHIKAEMGSER	ubiquitination	[2, 3]
361	GAPQELEKKSIHLPE	ubiquitination	[1]
362	APQELEKKSIHLPEK	ubiquitination	[1]
419	RNGMPLLKEVPRSYE	ubiquitination	[1]
429	PRSYELLKPPPICPR	ubiquitination	[1, 3]
444	DSVKVINKEGEVMDV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner. 

Sequence Annotation

 ZN_FING 118 140 C2H2-type 1.
 ZN_FING 146 168 C2H2-type 2.
 ZN_FING 174 196 C2H2-type 3.
 ZN_FING 202 224 C2H2-type 4; atypical.
 ZN_FING 452 474 C2H2-type 5.
 ZN_FING 480 504 C2H2-type 6; atypical.  

Keyword

 Alternative splicing; B-cell activation; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 509 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0007498; P:mesoderm development; TAS:ProtInc.
 GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
 GO:0045577; P:regulation of B cell differentiation; ISS:UniProtKB.
 GO:0030888; P:regulation of B cell proliferation; ISS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS