CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Origin recognition complex subunit 3 
Protein Synonyms/Alias
 Origin recognition complex subunit Latheo 
Gene Name
 ORC3 
Gene Synonyms/Alias
 LATHEO; ORC3L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32PIEDYFNKGKNEPEDubiquitination[1]
34EDYFNKGKNEPEDSKubiquitination[2]
41KNEPEDSKLRFETYQubiquitination[1]
55QLIWQQMKSENERLQubiquitination[1]
165CCVDIKSKEEESVHVubiquitination[1]
383VEKQASEKQVALLTNubiquitination[1]
428KFTSSLPKYPLGRQIubiquitination[1, 3]
492NHLGSTAKRIEEFLAubiquitination[2]
523SQPKGLQKTDLYHLQubiquitination[2, 3]
531TDLYHLQKSLLEMKEubiquitination[2]
611NNPYYYLKNEALKSEubiquitination[1, 2, 4]
616YLKNEALKSEEGCIPubiquitination[2]
694LELLGFIKPTKQKTDubiquitination[1, 2]
699FIKPTKQKTDHVARLubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. 
Sequence Annotation
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 516 516 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; DNA replication; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 711 AA 
Protein Sequence
MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI WQQMKSENER 60
LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI PTAALVLGVN VTDHDLTFGS 120
LTEALQNNVT PYVVSLQAKD CPDMKHFLQK LISQLMDCCV DIKSKEEESV HVTQRKTHYS 180
MDSLSSWYMT VTQKTDPKML SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH 240
LHEFPLILIF GIATSPIIIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF 300
KINEKVLQVL TNIFLYHDFS VQNFIKGLQL SLLEHFYSQP LSVLCCNLPE AKRRINFLSN 360
NQCENIRRLP SFRRYVEKQA SEKQVALLTN ERYLKEETQL LLENLHVYHM NYFLVLRCLH 420
KFTSSLPKYP LGRQIRELYC TCLEKNIWDS EEYASVLQLL RMLAKDELMT ILEKCFKVFK 480
SYCENHLGST AKRIEEFLAQ FQSLDETKEE EDASGSQPKG LQKTDLYHLQ KSLLEMKELR 540
RSKKQTKFEV LRENVVNFID CLVREYLLPP ETQPLHEVVY FSAAHALREH LNAAPRIALH 600
TALNNPYYYL KNEALKSEEG CIPNIAPDIC IAYKLHLECS RLINLVDWSE AFATVVTAAE 660
KMDANSATSE EMNEIIHARF IRAVSELELL GFIKPTKQKT DHVARLTWGG C 711 
Gene Ontology
 GO:0005664; C:nuclear origin of replication recognition complex; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003688; F:DNA replication origin binding; TAS:ProtInc.
 GO:0006260; P:DNA replication; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR020795; ORC3. 
Pfam
 PF07034; ORC3_N 
SMART
  
PROSITE
  
PRINTS