CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lathosterol oxidase 
Protein Synonyms/Alias
 C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase 
Gene Name
 Sc5d 
Gene Synonyms/Alias
 Sc5dl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
70MKHPQFLKNQVSREIubiquitination[1]
255DRIGGSFKHPSSFEGubiquitination[1]
263HPSSFEGKGPHSYVKubiquitination[1]
270KGPHSYVKNMTEKESubiquitination[1]
275YVKNMTEKESNSFAEubiquitination[1]
286SFAENGCKGKKVSNGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. 
Sequence Annotation
 MOTIF 138 143 Histidine box-1.
 MOTIF 151 155 Histidine box-2.
 MOTIF 228 233 Histidine box-3.
 MOD_RES 253 253 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MDLVLSAADY YFFTPYVYPA TWPEDNIIRQ TISLLIVTNL GAYILYFFCA TLSYYFVYDH 60
SLMKHPQFLK NQVSREIVFT VKSLPWISIP TVSLFLLELR GYSKLYDDIG DFPNGWIHLM 120
VSVVSFLFFT DMLIYRIHRG LHHRLVYKRI HKPHHIWKIP TPFASHAFHP VDGFLQSLPY 180
HIYPFVFPLH KVVYLGLYVL VNVWTISIHD GDFRVPQILR PFINGSAHHT DHHMFFDYNY 240
GQYFTLWDRI GGSFKHPSSF EGKGPHSYVK NMTEKESNSF AENGCKGKKV SNGEFTKNK 299 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050046; F:lathosterol oxidase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
 GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR006694; Fatty_acid_hydroxylase. 
Pfam
 PF04116; FA_hydroxylase 
SMART
  
PROSITE
  
PRINTS