CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Propionyl-CoA carboxylase beta chain, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Pccb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101DFGMAADKNKFPGDSacetylation[1, 2, 3, 4]
101DFGMAADKNKFPGDSsuccinylation[3]
103GMAADKNKFPGDSVVacetylation[2, 3, 4, 5]
103GMAADKNKFPGDSVVsuccinylation[3]
439GAVEIIFKGHQDVEAacetylation[2, 3, 4]
439GAVEIIFKGHQDVEAsuccinylation[3]
454AQAEYVEKFANPFPAacetylation[2, 3, 4]
454AQAEYVEKFANPFPAsuccinylation[3]
490DLEVLASKKVHRPWRacetylation[2]
Reference
 [1] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MAAAIRIRAV AAGARLSVLN CGLGITTRGL CSQPVSVKER IDNKRHAALL GGGQRRIDAQ 60
HKRGKLTARE RISLLLDPGS FMESDMFVEH RCADFGMAAD KNKFPGDSVV TGRGRINGRL 120
VYVFSQDFTV FGGSLSGAHA QKICKIMDQA ITVGAPVIGL NDSGGARIQE GVESLAGYAD 180
IFLDTSYLFI TGPEVVKSVT NEDVTQEQLG GAKTHTTVSG VAHRAFDNDV DALCNLREFF 240
NFLPLSSQDP APIRECHDPS DRLVPELDTV VPLESSKAYN MLDIIHAVID EREFFEIMPS 300
YAKNIVVGFA RMNGRTVGIV GNQPNVASGC LDINSSVKGA RFVRFCDAFN IPLITFVDVP 360
GFLPGTAQEY GGIIRHGAKL LYAFAEATVP KITVITRKAY GGAYDVMSSK HLLGDTNYAW 420
PTAEIAVMGA KGAVEIIFKG HQDVEAAQAE YVEKFANPFP AAVRGFVDDI IQPSSTRARI 480
CCDLEVLASK KVHRPWRKHA NIPL 504 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004658; F:propionyl-CoA carboxylase activity; ISS:MGI. 
Interpro
 IPR000022; Carboxyl_trans.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N. 
Pfam
 PF01039; Carboxyl_trans 
SMART
  
PROSITE
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER 
PRINTS