UniProt Accession

 CDKN3_HUMAN; Q16667; Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051; Q9C053 

Genbank Protein ID

 U02681; L27711; AF213033; AF213036; AF213038; AF213039; AF213041; AF213042; AF213046; AF213047; AF213049; AF213053; AY257474; L25876; EF560750; CR407666; BT019451; AY194117; CH471061; CH471061; BC064965 

Genbank Nucleotide ID

 AAC04932.1; AAA66496.1; AAK06365.1; AAK06368.1; AAK06370.1; AAK06371.1; AAK06373.1; AAK06374.1; AAK06377.1; AAK06378.1; AAK06380.1; AAK06384.1; AAP13062.1; AAA60222.1; ABQ59060.1; CAG28594.1; AAV38258.1; AAN86348.1; EAW80632.1; EAW80634.1; AAH64965.1 

Protein Name

 Cyclin-dependent kinase inhibitor 3 

Protein Synonyms/Alias

 CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase 

Gene Name

 CDKN3 

Gene Synonyms/Alias

 CDI1; CIP2; KAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	LCALPGCKFKDVRRN	ubiquitination	[1]
54	ALPGCKFKDVRRNVQ	ubiquitination	[1]
86	CTRGELSKYRVPNLL	ubiquitination	[1, 2, 3]
135	TCLKNYRKTLIHCYG	ubiquitination	[1]
184	SGAIQTIKQYNYLHE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. 

Sequence Annotation

 REGION 1 34 Interaction with CDK2.
 ACT_SITE 140 140 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Disease mutation; Hydrolase; Polymorphism; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:MGI.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:MGI.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; TAS:ProtInc.
 GO:0007050; P:cell cycle arrest; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc. 

Interpro

 IPR008425; CDK_inhib_3.
 IPR022778; CDKN3.
 IPR000387; Tyr/Dual-sp_Pase. 

Pfam

 PF05706; CDKN3 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 

PRINTS