UniProt Accession

 PEBB_MOUSE; Q08024; Q08025; Q62050; Q62051; Q8C282; Q8CGD5 

Genbank Protein ID

 D14572; D14571; D14570; D14569; L03305; L03306; L03279; AK089094; BC006763; BC026749; BC040752 

Genbank Nucleotide ID

 BAA03426.1; BAA03425.1; BAA03424.1; BAA03423.1; BAC40748.1; AAH06763.1; AAH26749.1; AAH40752.2 

Protein Name

 Core-binding factor subunit beta 

Protein Synonyms/Alias

 CBF-beta; Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit 

Gene Name

 Cbfb 

Gene Synonyms/Alias

 Pebp2b; Pebpb2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	LSRECEIKYTGFRDR	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. 

Sequence Annotation

 MOD_RES 10 10 Phosphoserine; by CK2 (Potential).
 MOD_RES 159 159 Phosphoserine; by PKC (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0048469; P:cell maturation; IMP:MGI.
 GO:0060216; P:definitive hemopoiesis; IMP:MGI.
 GO:0030098; P:lymphocyte differentiation; IMP:MGI.
 GO:0030099; P:myeloid cell differentiation; IMP:MGI.
 GO:0001649; P:osteoblast differentiation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. 

Interpro

 IPR003417; CBF_beta. 

Pfam

 PF02312; CBF_beta 

SMART

  

PROSITE

  

PRINTS