CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001634
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetylserotonin O-methyltransferase-like protein 
Protein Synonyms/Alias
 ASMTL 
Gene Name
 ASMTL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41RFEVVPSKFKEKLDKubiquitination[1, 2]
48KFKEKLDKASFATPYubiquitination[3]
63GYAMETAKQKALEVAubiquitination[4]
65AMETAKQKALEVANRubiquitination[3]
76VANRLYQKDLRAPDVubiquitination[3]
133AIVHCSSKDHQLDTRubiquitination[5]
308LLTACKLKVFDLLKDubiquitination[1, 2, 3]
320LKDEAPQKAADIASKubiquitination[5]
327KAADIASKVDASACGubiquitination[3]
409HHRALGKKAEDLFQDubiquitination[3, 5]
437RAMHGMTKLTACQVAubiquitination[3]
547SRVAESCKPGAGLLLubiquitination[3]
563ETLLDEEKRVAQRALubiquitination[3]
583MLVQTEGKERSLGEYubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. 
Sequence Annotation
 REGION 11 223 MAF-like.
 REGION 277 621 ASMT-like.
 ACT_SITE 44 44 Potential.
 MOD_RES 239 239 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 621 AA 
Protein Sequence
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME 60
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS 120
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA 180
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD 240
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG 300
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET 360
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ 420
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV 480
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS 540
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH 600
QVQVVHLGGV LDAILATKVA P 621 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0008171; F:O-methyltransferase activity; IEA:InterPro. 
Interpro
 IPR025772; ASMT-like.
 IPR003697; Maf.
 IPR001077; O_MeTrfase_2.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF02545; Maf
 PF00891; Methyltransf_2 
SMART
  
PROSITE
  
PRINTS