UniProt Accession

 PDXK_ECOLI; P40191; P76964 

Genbank Protein ID

 U53700; U00096; AP009048; M21994; J02796 

Genbank Nucleotide ID

 AAC44166.1; AAC75471.1; BAA16292.1 

Protein Name

 Pyridoxine kinase 

Protein Synonyms/Alias

 PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase 

Gene Name

 pdxK 

Gene Synonyms/Alias

 yfeI; b2418; JW2411 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
10	SLLLFNDKSRALQAD	acetylation	[1]
182	DSAIAAAKSLLSDTL	acetylation	[1, 2]
229	SRVKTDLKGTGDLFC	acetylation	[1]
245	QLISGLLKGKALTDA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates. 

Sequence Annotation

 NP_BIND 195 196 ATP (By similarity).
 NP_BIND 220 232 ATP (By similarity).
 BINDING 23 23 Substrate (By similarity).
 BINDING 136 136 Substrate (By similarity).
 BINDING 233 233 Substrate (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IPI:EcoliWiki.
 GO:0004340; F:glucokinase activity; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IPI:EcoliWiki.
 GO:0008478; F:pyridoxal kinase activity; IDA:EcoliWiki.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0051156; P:glucose 6-phosphate metabolic process; IEA:GOC.
 GO:0006096; P:glycolysis; IEA:HAMAP.
 GO:0009443; P:pyridoxal 5'-phosphate salvage; IEA:InterPro.
 GO:0008615; P:pyridoxine biosynthetic process; IDA:EcoliWiki. 

Interpro

 IPR013749; HMP-P_kinase-1.
 IPR004625; PyrdxlP_synth_PyrdxlKinase.
 IPR023479; Pyridoxal_kinase. 

Pfam

 PF08543; Phos_pyr_kin 

SMART

  

PROSITE

  

PRINTS