| Tag | Content |
|---|
| CPLM ID | CPLM-001084 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingomyelin phosphodiesterase 2 |
Protein Synonyms/Alias | Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral sphingomyelinase; N-SMase; nSMase |
Gene Name | Smpd2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 319 | ELGLGIAKARWWAAF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (By similarity). |
Sequence Annotation | ACT_SITE 272 272 Proton acceptor (By similarity).
METAL 49 49 Magnesium (By similarity). |
Keyword | Complete proteome; Hydrolase; Lipid metabolism; Magnesium; Membrane; Metal-binding; Reference proteome; Sphingolipid metabolism; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 419 AA |
Protein Sequence | MKLNFSLRLR VFNLNCWDIP YLSKHRADRM KRLGDFLNLE NFDLALLEEV WSEQDFQYLR 60
QRLSLTYPDA HYFRSGMIGS GLCVFSKHPI QEIFQHVYSL NGYPYMFHHG DWFCGKSVGL 120
LVLRLSGLVL NAYVTHLHAE YSRQKDIYFA HRVAQAWELA QFIHHTSKNA DVVLLCGDLN 180
MHPKDLGCCL LKEWTGLHDA FVETEDFKGS DDGCTMVPKN CYVSQQDLGP FPSGIRIDYV 240
LYKAVSEFHV CCETLKTTTG CDPHSDKPFS DHEALMATLY VKHSPPQEDP CTACGPLERS 300
DLISVLREAR TELGLGIAKA RWWAAFSGYV IVWGLSLLVL LCVLAAGEEA REVAIILCIP 360
SVGLVLVAGA VYLFHKQEAK GLCRAQAEML HVLTRETETQ DRGSEPHLAY CLQQEGDRA 419 |
Gene Ontology | GO:0005901; C:caveola; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004767; F:sphingomyelin phosphodiesterase activity; IMP:MGI. GO:0046513; P:ceramide biosynthetic process; IEA:Compara. GO:0007243; P:intracellular protein kinase cascade; IEA:Compara. GO:0009612; P:response to mechanical stimulus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |