CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037559
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho GTPase-activating protein 27 
Protein Synonyms/Alias
  
Gene Name
 ARHGAP27 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
529GGLRQPSKFSTPEYTubiquitination[1]
721GNLATIQKLRYKVDHubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 867 AA 
Protein Sequence
MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP 60
AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL 120
CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA 180
CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP 240
GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS 300
LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE 360
TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQWVRL 420
EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR SIHKSSQDGD TPAQASPPEE KTKTLDKAGV 480
LHRTKTADKG KRLRKKHWSA SWTVLEGGVL TFFKDSKTSA AGGLRQPSKF STPEYTVELR 540
GATLSWAPKD KSSRKNVLEL RSRDGSEYLI QHDSEAIIST WHKAIAQGIQ ELSAELPPEE 600
SESSRVDFGS SERLGSWQEK EEDARPNAAA PALGPVGLES DLSKVRHKLR KFLQRRPTLQ 660
SLREKGYIKD QVFGCALAAL CERERSRVPR FVQQCIRAVE ARGLDIDGLY RISGNLATIQ 720
KLRYKVDHDE RLDLDDGRWE DVHVITGALK LFFRELPEPL FPFSHFRQFI AAIKLQDQAR 780
RSRCVRDLVR SLPAPNHDTL RMLFQHLCRV IEHGEQNRMS VQSVAIVFGP TLLRPEVEET 840
SMPMTMVFQN QVVELILQQC ADIFPPH 867 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015767; Rho_GTPase_activating.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001452; SH3_domain.
 IPR001202; WW_dom. 
Pfam
 PF00169; PH
 PF00620; RhoGAP
 PF00397; WW 
SMART
 SM00233; PH
 SM00324; RhoGAP
 SM00326; SH3
 SM00456; WW 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP
 PS50002; SH3
 PS50020; WW_DOMAIN_2 
PRINTS