UniProt Accession

 IF6_DROME; P56538; Q8MLQ6; Q9W1I5 

Genbank Protein ID

 X97641; AE013599; AY094688 

Genbank Nucleotide ID

 AAF47074.1; AAM11041.1 

Protein Name

 Eukaryotic translation initiation factor 6 

Protein Synonyms/Alias

 eIF-6 

Gene Name

 eIF6 

Gene Synonyms/Alias

 CG17611 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
93	NSLPDAVKIYRVEER	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:FlyBase.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0043023; F:ribosomal large subunit binding; IEA:HAMAP.
 GO:0043022; F:ribosome binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0042256; P:mature ribosome assembly; IEA:HAMAP.
 GO:0042273; P:ribosomal large subunit biogenesis; IEA:HAMAP. 

Interpro

 IPR002769; eIF6. 

Pfam

 PF01912; eIF-6 

SMART

 SM00654; eIF6 

PROSITE

  

PRINTS