CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043691
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear body protein SP140-like protein 
Protein Synonyms/Alias
  
Gene Name
 SP140L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
87DRELITNKMFEDSEDubiquitination[1]
145IHIYKSFKNAIQDKLubiquitination[1]
151FKNAIQDKLSFQESDubiquitination[1]
160SFQESDRKEREERPDubiquitination[1, 2]
169REERPDIKLSLKQGEubiquitination[1, 3, 4]
173PDIKLSLKQGEVPESubiquitination[1, 2, 5]
185PESPEARKESDQACGubiquitination[3]
193ESDQACGKMDTVDIAubiquitination[3]
207ANNSTLGKPKRKRRKubiquitination[2, 3]
229RMGTRTQKNNQQNDNubiquitination[1]
238NQQNDNSKADGQLVSubiquitination[1, 2, 3, 4, 5]
248GQLVSSEKKANMNLKubiquitination[1, 2, 4]
249QLVSSEKKANMNLKDubiquitination[1]
255KKANMNLKDLSKIRGubiquitination[1, 4]
299CIQTEDGKWFTPMEFubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MAGGGSDLST RGLNGGVSQV ANEMNHLPAH SQSLQRLFTE DQDVDEGLVY DTVFKHFKRH 60
KLEISNAIKK TFPFLEGLRD RELITNKMFE DSEDSCRNLV PVQRVVYNVL SELEKTFNLS 120
VLEALFSEVN MQEYPDLIHI YKSFKNAIQD KLSFQESDRK EREERPDIKL SLKQGEVPES 180
PEARKESDQA CGKMDTVDIA NNSTLGKPKR KRRKKKGHGW SRMGTRTQKN NQQNDNSKAD 240
GQLVSSEKKA NMNLKDLSKI RGRKRGKPGT HFTQSDRAPQ KRVRSRGTLA KCIQTEDGKW 300
FTPMEFEIKG GYARSKNWRL SVRCGGWPLR RLMEEGSLPN PPRIYYRNKK RILKSQNNSS 360
VDPCMRNLDE CEVCRDGGEL FCCDTCSRVF HEDCHIPPVE SEK 403 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR000770; SAND_dom.
 IPR010919; SAND_dom-like.
 IPR004865; Sp100.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01342; SAND
 PF03172; Sp100 
SMART
 SM00258; SAND 
PROSITE
 PS51414; HSR
 PS50864; SAND 
PRINTS