UniProt Accession

 MLP3A_RAT; Q6XVN8 

Genbank Protein ID

 AY206668; BC086389 

Genbank Nucleotide ID

 AAP42560.1; AAH86389.1 

Protein Name

 Microtubule-associated proteins 1A/1B light chain 3A 

Protein Synonyms/Alias

 Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha 

Gene Name

 Map1lc3a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
51	LPVLDKTKFLVPDHV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). 

Sequence Annotation

 MOD_RES 12 12 Phosphoserine; by PKA (By similarity).
 LIPID 120 120 Phosphatidylethanolamine amidated glycine  

Keyword

 Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Direct protein sequencing; Lipoprotein; Membrane; Microtubule; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IDA:RGD.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IDA:RGD.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0008429; F:phosphatidylethanolamine binding; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IDA:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IEA:Compara. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS