CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Minor histocompatibility antigen HA-1 
Protein Synonyms/Alias
  
Gene Name
 HMHA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
188DLISYLEKRTTLEMEacetylation[1]
367KQELEDTKVTALRQIubiquitination[2]
620ECCLACHKKCLETLAubiquitination[1, 2, 3]
621CCLACHKKCLETLAIubiquitination[1, 2]
717HDISNVLKLYLRQLPubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1019 AA 
Protein Sequence
MCICGTAHPV LDEGPVRCRA GPRDLLEARR PRAHECLGEA LRVMHQIISK YPLLNTVETL 60
TAAGTLIAKV KAFHYESNND LEKQEFEKAL ETIAVAFSST VSEFLMGEVD SSTLLAVPPG 120
DSSQSMESLY GPGSEGTPPS LEDCDAGCLP AEEVDVLLQR CEGGVDAALL YAKNMAKYMK 180
DLISYLEKRT TLEMEFAKGL QKIAHNCRQS VMQEPHMPLL SIYSLALEQD LEFGHSMVQA 240
VGTLQTQTFM QPLTLRRLEH EKRRKEIKEA WHRAQRKLQE AESNLRKAKQ GYVQRCEDHD 300
KARFLVAKAE EEQAGSAPGA GSTATKTLDK RRRLEEEAKN KAEEAMATYR TCVADAKTQK 360
QELEDTKVTA LRQIQEVIRQ SDQTIKSATI SYYQMMHMQT APLPVHFQML CESSKLYDPG 420
QQYASHVRQL QRDQEPDVHY DFEPHVSANA WSPVMRARKS SFNVSDVARP EAAGSPPEEG 480
GCTEGTPAKD HRAGRGHQVH KSWPLSISDS DSGLDPGPGA GDFKKFERTS SSGTMSSTEE 540
LVDPDGGAGA SAFEQADLNG MTPELPVAVP SGPFRHEGLS KAARTHRLRK LRTPAKCREC 600
NSYVYFQGAE CEECCLACHK KCLETLAIQC GHKKLQGRLQ LFGQDFSHAA RSAPDGVPFI 660
VKKCVCEIER RALRTKGIYR VNGVKTRVEK LCQAFENGKE LVELSQASPH DISNVLKLYL 720
RQLPEPLISF RLYHELVGLA KDSLKAEAEA KAASRGRQDG SESEAVAVAL AGRLRELLRD 780
LPPENRASLQ YLLRHLRRIV EVEQDNKMTP GNLGIVFGPT LLRPRPTEAT VSLSSLVDYP 840
HQARVIETLI VHYGLVFEEE PEETPGGQDE SSNQRAEVVV QVPYLEAGEA VVYPLQEAAA 900
DGCRESRVVS NDSDSDLEEA SELLSSSEAS ALGHLSFLEQ QQSEASLEVA SGSHSGSEEQ 960
LEATAREDGD GDEDGPAQQL SGFNTNQSNN VLQAPLPPMR LRGGRMTLGS CRERQPEFV 1019 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001060; FCH_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00620; RhoGAP 
SMART
 SM00109; C1
 SM00055; FCH
 SM00324; RhoGAP 
PROSITE
 PS50238; RHOGAP
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS