CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028277
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Tgm2 
Protein Synonyms/Alias
 Tissue-type transglutaminase; Transglutaminase 2, C polypeptide, isoform CRA_a 
Gene Name
 Tgm2 
Gene Synonyms/Alias
 TgaseII; rCG_32083 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
74PSEEAGTKARFSLSDacetylation[1]
380PVSVRAIKEGDLSTKacetylation[1]
414QSDGSVLKSINNSLVacetylation[1]
589YLENPEIKIRILGEPacetylation[1]
601GEPKQNRKLVAEVSLacetylation[1]
648VPAGDAVKVRVDLFPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 277 277 By similarity.
 ACT_SITE 335 335 By similarity.
 ACT_SITE 358 358 By similarity.
 METAL 398 398 Calcium (By similarity).
 METAL 400 400 Calcium (By similarity).
 METAL 447 447 Calcium (By similarity).
 METAL 452 452 Calcium (By similarity).  
Keyword
 Calcium; Complete proteome; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY EASVDRLTFG 60
AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL SLQLCTPANA PVGQYRLSLE 120
TSTGYQGSSF MLGHFILLFN AWCPADDVYL DSEAERREYV LTQQGFIYQG SVKFIKSVPW 180
NFGQFEDGIL DACLMLLDVN PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR 240
WDNNYGDGIS PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG YEGWQAIDPT 360
PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD VVDWIRQSDG SVLKSINNSL 420
VVGQKISTKS VGRDDREDIT YTYKYPEGSP EEREVFTRAN HLNKLAEKEE TGVAMRIRVG 480
DGMSLGNDFD VFAHIGNDTS ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS 540
IPLRILYEKY SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 600
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR VDLFPTDIGL 660
HKLVVNFQCD KLKSVKGYRN IIIGPA 686 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0019899; F:enzyme binding; IC:RGD.
 GO:0005525; F:GTP binding; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IDA:RGD.
 GO:0043277; P:apoptotic cell clearance; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IMP:RGD.
 GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Compara.
 GO:0051482; P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IMP:RGD.
 GO:0006917; P:induction of apoptosis; IDA:RGD.
 GO:0018153; P:isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; IDA:RGD.
 GO:0045785; P:positive regulation of cell adhesion; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:RGD.
 GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:RGD.
 GO:0051260; P:protein homooligomerization; IDA:RGD.
 GO:0060662; P:salivary gland cavitation; IEA:Compara. 
Interpro
 IPR023608; Gln_gamma-glutamylTfrase_euk.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002931; Transglutaminase-like.
 IPR008958; Transglutaminase_C.
 IPR013808; Transglutaminase_CS.
 IPR001102; Transglutaminase_N. 
Pfam
 PF00927; Transglut_C
 PF01841; Transglut_core
 PF00868; Transglut_N 
SMART
 SM00460; TGc 
PROSITE
 PS00547; TRANSGLUTAMINASES 
PRINTS