CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein MON2 
Protein Synonyms/Alias
  
Gene Name
 MON2 
Gene Synonyms/Alias
 YSL2; YNL297C; N0453 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
577TSPVESTKNPSRSIAubiquitination[1]
814NSDEQDNKVKQFGTLubiquitination[1]
1347KHILRILKNLAEIIKacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure. 
Sequence Annotation
 REGION 60 410 Golgi membrane targeting and interaction
 REGION 1501 1636 Required for function in membrane
 MOD_RES 564 564 Phosphoserine.
 MOD_RES 567 567 Phosphoserine.
 MOD_RES 571 571 Phosphoserine.  
Keyword
 Complete proteome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1636 AA 
Protein Sequence
MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF EELERHPDFA 60
LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL DAFIEATHLA MEIQLKVLQV 120
VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV PNKAPVVVGT ASATLQQLID EIFDRLSIES 180
VVDDKQYEVL ISNSESIKVN VYRYDANKLF DNICSLNEIS SNGAVSDEEM LLDIGDIPID 240
YGLEILESIL KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS SSRHFSTAVR SCRCLKLLIR 300
KEYLSILELE LEVILSLLIH GISVESNLSG WQRVLSLELF KDLSQDPEIV NTLYMDYDNY 360
PDKKHVFKYL LKECIVLLNS PEYITFLAPS KVVEKMDSPL ITTENSTVKT KFMHLLDKSN 420
APSINITYII SLILTICNHL CEGLNKSALE SSPLEKKIED KEREEGTGND STVVKVYSGL 480
FSGLFELNKL FLYSTSLETS IFHLVVRAFQ KLAHSAGVLS LKDKLRACMK LFSILITNNV 540
TSSNQYSFND TSKSAKNQHT RNISTSSVTT SPVESTKNPS RSIADSAQNK EMKRRLHPRN 600
ISSRQVSLLR ALISLSISLG PIFDSESWRY TFLTWQWITY YIYGPSADFK ESFYSEDIPP 660
PPILTKSDVT SIESSLTKFF ESTSSYSCST FHLVLTRLIL DSKNTLTLEQ TNLNLNNDIG 720
YHPLDAKDEI IPCIYNKAFF VNKIGELATY NCKKFLFGKN GKELWSLIST YMIKLISNRE 780
MDNDSLRLYT VRVFTDIIKK ATNEVGNSDE QDNKVKQFGT LENLVIDSLM ATINSIKQLD 840
IGKQEIYNGT INVESDILFQ LLLTLKEILN EFGELLMNSW TNIFNIINSP FEWTVEDTDF 900
SVNEDIDDSS LFEGIVQKHK NMIQVSYDVF KLISDDFLQS LPMSVIKFVI DTLVNFVSQK 960
RNLNISFSSI SQFWLVGDYL RVRFNPETLN LSDEKRRSLS EKINNQKLIE IITSSSSHDW 1020
ELYNGLWIYL LKNLINCTND DRVEVKNGAV QTFFRIIDSH SVCFPPWDLI FLEVIEPLLT 1080
KEWSTEELEN ETDFINVTLQ GLIKLYPEHF KDFKNNTTCA KEWSMLLDFL KRLLSSTSNN 1140
TKNAVILNYQ TLLKEIITIE DVPSDILKKC CEIFTDYNIT YSDLSTNASS KTEYDCIYEL 1200
ITGFPPLYQL ISKYDAMTDE FVEKVLLLFN SAIKYPLLPE FVQDKTKPSS MQKAILSGLD 1260
IFMTNDSKDT EILILLQLST ISILAFDTRE KITKKLGPKL PKASLNRLPT FEAISYMSCS 1320
NLRNRIAKID QFGISTLKAK HILRILKNLA EIIKRKSLIT GSESDEIPIW VLASNCFCDL 1380
SNKIFKSLQE DAENPLKDNF CDLFINVIVV TLQRINPELD NLTEIDDLNE YSKYREILLE 1440
NRIIDLFNER QLDTFIYAVW DCSFLYEFDE LENALMQDCG TFSELSQKLS SFDFSCIFGS 1500
TTNPRFQTKY KCSLECLQDL VNFMLNTNEK LRKLTAPYLS ARIALALRRY ISDEYLIGRA 1560
PIPKLRKTEL ATLLNGLCVI LRGVLDQNST LGNKQIGVEN LQTLSPLILR TIPVSHKMDG 1620
LQDKVLELSL GFTKLD 1636 
Gene Ontology
 GO:0005829; C:cytosol; TAS:SGD.
 GO:0005768; C:endosome; IDA:SGD.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; IDA:SGD.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IPI:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0006895; P:Golgi to endosome transport; IMP:HGNC.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD. 
Interpro
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS