UniProt Accession

 F1LWH6_RAT; F1LWH6 

Genbank Protein ID

 AABR06006958 

Genbank Nucleotide ID

  

Protein Name

 Methyl-CpG-binding protein 2 

Protein Synonyms/Alias

  

Gene Name

 Mecp2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
41	KKEDKEGKHEPLQPS	acetylation	[1]
218	VLEKSPGKLLVKMPF	acetylation	[1]
320	IEVKEVVKPLLVSTL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000792; C:heterochromatin; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0010385; F:double-stranded methylated DNA binding; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0035197; F:siRNA binding; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0032048; P:cardiolipin metabolic process; IEA:Compara.
 GO:0050432; P:catecholamine secretion; IEA:Compara.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0006342; P:chromatin silencing; IEA:Compara.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0006541; P:glutamine metabolic process; IEA:Compara.
 GO:0016573; P:histone acetylation; IEA:Compara.
 GO:0016571; P:histone methylation; IEA:Compara.
 GO:0006020; P:inositol metabolic process; IEA:Compara.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0031061; P:negative regulation of histone methylation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IEA:Compara.
 GO:0042551; P:neuron maturation; IEA:Compara.
 GO:0009405; P:pathogenesis; IEA:Compara.
 GO:0046470; P:phosphatidylcholine metabolic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0051965; P:positive regulation of synapse assembly; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0019230; P:proprioception; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Compara.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0001964; P:startle response; IEA:Compara.
 GO:0007416; P:synapse assembly; IEA:Compara.
 GO:0021591; P:ventricular system development; IEA:Compara.
 GO:0008542; P:visual learning; IEA:Compara. 

Interpro

 IPR017956; AT_hook_DNA-bd_motif.
 IPR016177; DNA-bd_integrase-typ.
 IPR017353; Me_CpG-bd_MeCP2.
 IPR001739; Methyl_CpG_DNA-bd. 

Pfam

 PF01429; MBD 

SMART

 SM00384; AT_hook
 SM00391; MBD 

PROSITE

 PS50982; MBD 

PRINTS