UniProt Accession

 TACT_HUMAN; P40200; Q5JPB3 

Genbank Protein ID

 M88282; AL833681; CH471052 

Genbank Nucleotide ID

 AAA36662.1; CAI46155.1; EAW79698.1 

Protein Name

 T-cell surface protein tactile 

Protein Synonyms/Alias

 Cell surface antigen CD96; T cell-activated increased late expression protein; CD96 

Gene Name

 CD96 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
224	TLLKDRVKLGTDYRL	ubiquitination	[1]
255	HIRVGPNKILRSSTT	ubiquitination	[1]
268	TTVKVFAKPEIPVIV	ubiquitination	[1]
293	RRFTCLLKNVFPKAN	ubiquitination	[1]
325	YITNEERKGKDGFLE	ubiquitination	[1]
327	TNEERKGKDGFLELK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. 

Sequence Annotation

 DOMAIN 38 125 Ig-like V-type 1.
 DOMAIN 156 238 Ig-like V-type 2.
 DOMAIN 269 375 Ig-like C2-type.
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
 CARBOHYD 148 148 N-linked (GlcNAc...) (Potential).
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
 CARBOHYD 200 200 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
 CARBOHYD 277 277 N-linked (GlcNAc...).
 CARBOHYD 278 278 N-linked (GlcNAc...).
 CARBOHYD 300 300 N-linked (GlcNAc...) (Potential).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 435 435 N-linked (GlcNAc...) (Potential).
 CARBOHYD 497 497 N-linked (GlcNAc...) (Potential).
 DISULFID 45 118 Probable.
 DISULFID 163 247 Probable.
 DISULFID 290 355 Probable.  

Keyword

 Alternative splicing; Cell adhesion; Chromosomal rearrangement; Complete proteome; Craniosynostosis; Disease mutation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 585 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0050776; P:regulation of immune response; TAS:Reactome. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub. 

Pfam

  

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS