| Tag | Content |
|---|
| CPLM ID | CPLM-012131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acid ceramidase |
Protein Synonyms/Alias | AC; ACDase; Acid CDase; Acylsphingosine deacylase; N-acylsphingosine amidohydrolase; Putative 32 kDa heart protein; PHP32; Acid ceramidase subunit alpha; Acid ceramidase subunit beta |
Gene Name | ASAH1 |
Gene Synonyms/Alias | ASAH; HSD-33; HSD33 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 92 | NTFVPSGKIMQVVDE | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. |
Sequence Annotation | CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
CARBOHYD 259 259 N-linked (GlcNAc...).
CARBOHYD 286 286 N-linked (GlcNAc...).
CARBOHYD 342 342 N-linked (GlcNAc...) (Potential).
CARBOHYD 348 348 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Epilepsy; Glycoprotein; Hydrolase; Lysosome; Neurodegeneration; Polymorphism; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 395 AA |
Protein Sequence | MPGRSCVALV LLAAAVSCAV AQHAPPWTED CRKSTYPPSG PTYRGAVPWY TINLDLPPYK 60
RWHELMLDKA PVLKVIVNSL KNMINTFVPS GKIMQVVDEK LPGLLGNFPG PFEEEMKGIA 120
AVTDIPLGEI ISFNIFYELF TICTSIVAED KKGHLIHGRN MDFGVFLGWN INNDTWVITE 180
QLKPLTVNLD FQRNNKTVFK ASSFAGYVGM LTGFKPGLFS LTLNERFSIN GGYLGILEWI 240
LGKKDVMWIG FLTRTVLENS TSYEEAKNLL TKTKILAPAY FILGGNQSGE GCVITRDRKE 300
SLDVYELDAK QGRWYVVQTN YDRWKHPFFL DDRRTPAKMC LNRTSQENIS FETMYDVLST 360
KPVLNKLTVY TTLIDVTKGQ FETYLRDCPD PCIGW 395 |
Gene Ontology | GO:0043202; C:lysosomal lumen; TAS:Reactome. GO:0017040; F:ceramidase activity; TAS:Reactome. GO:0008219; P:cell death; IEA:UniProtKB-KW. GO:0006672; P:ceramide metabolic process; TAS:ProtInc. GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome. GO:0030324; P:lung development; IEA:Compara. GO:0010033; P:response to organic substance; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |