CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001516
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 152 kDa 
Protein Synonyms/Alias
 Cep152 
Gene Name
 CEP152 
Gene Synonyms/Alias
 KIAA0912 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
998NEVLAAAKEDFMKQKubiquitination[1]
1114ENADPEWKKRNMAELubiquitination[1]
1115NADPEWKKRNMAELSubiquitination[1]
1285KIMNAASKLATMAKLubiquitination[1]
1321SEMLIAVKKSKRNDVubiquitination[1]
1339IPCCIESKSNSVNTIubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation. 
Sequence Annotation
  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dwarfism; Mental retardation; Polymorphism; Primary microcephaly; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1710 AA 
Protein Sequence
MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE LQYSDCSEDG 60
TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK CGNVWEENRS KTEDRHPVYH 120
PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ 180
GPSCQGLEPY NKVTYKPYQS SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ 240
LQVLNKAKER QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER 300
EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE SLQRAREQHE 360
SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD HVKQLERNQE AIKLEKTEII 420
NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ FQLQQAQKAH AMSANMNKAL QEELTELKDE 480
ISLYESAAKL GIHPSDSEGE LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD 540
EFILKLKAEV QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS 600
EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ DLCNQMRQMV 660
QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE KQQLFEAYER THLQLRSELD 720
KLNKEVTAVQ ECYLEVCREK DNLELTLRKT TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT 780
IKAMKKKTLD CGSQTDQVTT SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE 840
IELELKHCEN ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS 900
FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR AELAKARSEW 960
NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED FMKQKTELLL QKETELQTCL 1020
DQSRREWTMQ EAKRIQLEIY QYEEDILTVL GVLLSDTQKE HISDSEDKQL LEIMSTCSSK 1080
WMSVQYFEKL KGCIQKAFQD TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG 1140
HHAQPLALQA TEAEAEENNK VVEELIEENN DMKNKLEELQ TLCKTPPRSL SAGAIENACL 1200
PCSGGALEEL RGQYIKAVKK IKCDMLRYIQ ESKERAAEMV KAEVLRERQE TARKMRKYYL 1260
ICLQQILQDD GKEGAEKKIM NAASKLATMA KLLETPISSK SQSKTTQSAL PLTSEMLIAV 1320
KKSKRNDVNQ KIPCCIESKS NSVNTITRTL CEQAPKRRAA CNLQRLLENS EHQSIKHVGS 1380
KETHLEFQFG DGSCKHLNSL PRNVSPEFVP CEGEGGFGLH KKKDLLSDNG SESLPHSAAY 1440
PFLGTLGNKP SPRCTPGPSE SGCMHITFRD SNERLGLKVY KCNPLMESEN AASEKSQGLD 1500
VQEPPVKDGG DLSDCLGWPS SSATLSFDSR EASFVHGRPQ GTLEIPSESV KSKQFSPSGY 1560
LSDTEESNMI CQTMKCQRYQ TPYLSEETTY LEPGKISVNC GHPSRHKADR LKSDFKKLSS 1620
TLPSSVCQQP SRKLIVPLSS QQDSGFDSPF VNLD 1654 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0051298; P:centrosome duplication; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS