UniProt Accession

 HNRLL_HUMAN; Q8WVV9; Q53T80; Q5JB51; Q659B9; Q8IVH5; Q8IVH6; Q96HR5 

Genbank Protein ID

 AY236963; AF461722; AF461712; AF461713; AF461715; AF461717; AF461719; AF461721; AF461720; AF461718; AF461716; AF461714; AF461716; AF461712; AF461713; AF461715; AF461714; AK291462; AC011247; BC008217; BC017480; AL512692 

Genbank Nucleotide ID

 AAQ20084.2; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76189.1; AAN76190.1; AAN76190.1; AAN76190.1; AAN76190.1; AAN76190.1; BAF84151.1; AAY24302.1; AAH08217.2; AAH17480.1; CAH56358.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein L-like 

Protein Synonyms/Alias

 hnRNPLL; Stromal RNA-regulating factor 

Gene Name

 HNRNPLL 

Gene Synonyms/Alias

 HNRPLL; SRRF; BLOCK24 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	EAGGSHHKVSVSPVV	ubiquitination	[1, 2]
222	VLCAQKAKAALNGAD	ubiquitination	[3]
261	NDSWDYTKPYLGRRD	ubiquitination	[1, 2, 3]
491	KYKVFDAKPSAKTLS	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. 

Sequence Annotation

 DOMAIN 76 150 RRM 1.
 DOMAIN 166 244 RRM 2.
 DOMAIN 335 409 RRM 3.
 MOD_RES 68 68 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 542 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:InterPro.
 GO:0033120; P:positive regulation of RNA splicing; IDA:UniProtKB. 

Interpro

 IPR006536; HnRNP-L_PTB.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

  

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS