CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 D-cysteine desulfhydrase 
Protein Synonyms/Alias
  
Gene Name
 dcyD 
Gene Synonyms/Alias
 yedO; b1919; JW5313 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
51PMAMGGNKLRKLEFLacetylation[1]
230SVADQLPKVVNLQQAacetylation[1]
302LIDGISQKRFKDEGPacetylation[1]
305GISQKRFKDEGPILFacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine. 
Sequence Annotation
 MOD_RES 51 51 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Direct protein sequencing; Lyase; Pyridoxal phosphate; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MPLHNLTRFP RLEFIGAPTP LEYLPRFSDY LGREIFIKRD DVTPMAMGGN KLRKLEFLAA 60
DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE NPIGTTAENY LTNGNRLLLD 120
LFNTQIEMCD ALTDPNAQLE ELATRVEAQG FRPYVIPVGG SNALGALGYV ESALEIAQQC 180
EGAVNISSVV VASGSAGTHA GLAVGLEHLM PESELIGVTV SRSVADQLPK VVNLQQAIAK 240
ELELTASAEI LLWDDYFAPG YGVPNDEGME AVKLLARLEG ILLDPVYTGK AMAGLIDGIS 300
QKRFKDEGPI LFIHTGGAPA LFAYHPHV 328 
Gene Ontology
 GO:0019148; F:D-cysteine desulfhydrase activity; IDA:EcoliWiki.
 GO:0046416; P:D-amino acid metabolic process; IDA:EcoliWiki.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006790; P:sulfur compound metabolic process; IDA:EcoliWiki. 
Interpro
 IPR027278; ACCD_DCysDesulf.
 IPR005966; D-Cys_desShydrase.
 IPR023702; D_Cys_desulphydr_bac.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00291; PALP 
SMART
  
PROSITE
  
PRINTS