CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial dicarboxylate carrier 
Protein Synonyms/Alias
 Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier 
Gene Name
 SLC25A10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138TVRLTEAKPVDKVKLacetylation[1, 2, 3]
142TEAKPVDKVKLIKEIacetylation[3]
150VKLIKEIKNYIQGINubiquitination[4]
409LGPLAFYKGLVPAGIubiquitination[5, 6]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY 60
PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM GGVMSGAVPA AAAQEAVEED 120
IPIAKERTHF TVRLTEAKPV DKVKLIKEIK NYIQGINLVQ AKKLVESLPQ EIKANVAKAE 180
AEKIKAALEA TQQEVKLRMT GMALRVVRTD GILALYSGLS ASLCRQMTYS LTRFAIYETV 240
RDRVAKGSQG PLPFHEKVLL GSVSGLAGGF VGTPADLVNV RMQNDVKLPQ GQRRNYAHAL 300
DGLYRVAREE GLRRLFSGAT MASSRGALVT VGQLSCYDQA KQLVLSTGYL SDNIFTHFVA 360
SFIAGGCATF LCQPLDVLKT RLMNSKGEYQ GVFHCAVETA KLGPLAFYKG LVPAGIRLIP 420
HTVLTFVFLE QLRKNFGIKV PS 442 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005840; C:ribosome; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006839; P:mitochondrial transport; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR002030; Mit_uncoupling.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom.
 IPR014719; Ribosomal_L7/12_C/ClpS-like.
 IPR013823; Ribosomal_L7/L12_C.
 IPR008932; Ribosomal_L7/L12_oligo. 
Pfam
 PF00153; Mito_carr
 PF00542; Ribosomal_L12 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00784; MTUNCOUPLING.