CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Selenoprotein N 
Protein Synonyms/Alias
 SelN 
Gene Name
 SEPN1 
Gene Synonyms/Alias
 SELN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174PETMTKSKDGFLGVSubiquitination[1, 2]
427VAMYPFKKVSYLPFTubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 67 102 EF-hand.
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).
 CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
 CARBOHYD 531 531 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Desmin-related myopathy; Disease mutation; Endoplasmic reticulum; Glycoprotein; Membrane; Myofibrillar myopathy; Reference proteome; Selenocysteine; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 590 AA 
Protein Sequence
MGRARPGQRG PPSPGPAAQP PAPPRRRARS LALLGALLAA AAAAAVRVCA RHAEAQAAAR 60
QELALKTLGT DGLFLFSSLD TDGDMYISPE EFKPIAEKLT GSCSVTQTGV QWCSHSSLQP 120
QLPWLNUSSC LSLLRSTPAA SCEEEELPPD PSEETLTIEA RFQPLLPETM TKSKDGFLGV 180
SRLALSGLRN WTAAASPSAV FATRHFQPFL PPPGQELGEP WWIIPSELSM FTGYLSNNRF 240
YPPPPKGKEV IIHRLLSMFH PRPFVKTRFA PQGAVACLTA ISDFYYTVMF RIHAEFQLSE 300
PPDFPFWFSP AQFTGHIILS KDATHVRDFR LFVPNHRSLN VDMEWLYGAS ESSNMEVDIG 360
YIPQMELEAT GPSVPSVILD EDGSMIDSHL PSGEPLQFVF EEIKWQQELS WEEAARRLEV 420
AMYPFKKVSY LPFTEAFDRA KAENKLVHSI LLWGALDDQS CUGSGRTLRE TVLESSPILT 480
LLNESFISTW SLVKELEELQ NNQENSSHQK LAGLHLEKYS FPVEMMICLP NGTVVHHINA 540
NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP 590 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR002048; EF_hand_dom. 
Pfam
  
SMART
  
PROSITE
 PS50222; EF_HAND_2 
PRINTS