UniProt Accession

 CRYAB_HUMAN; P02511; B0YIX0; O43416; Q9UC37; Q9UC38; Q9UC39; Q9UC40; Q9UC41 

Genbank Protein ID

 M28638; S45630; AF007162; AK314029; BT006770; EF444955; CH471065; BC007008; M24906 

Genbank Nucleotide ID

 AAA52104.1; AAB23453.1; AAC19161.1; BAG36739.1; AAP35416.1; ACA05949.1; EAW67162.1; AAH07008.1; AAA60267.1 

Protein Name

 Alpha-crystallin B chain 

Protein Synonyms/Alias

 Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component 

Gene Name

 CRYAB 

Gene Synonyms/Alias

 CRYA2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	FSVNLDVKHFSPEEL	ubiquitination	[1]
92	SPEELKVKVLGDVIE	acetylation	[2, 3, 4]
92	SPEELKVKVLGDVIE	ubiquitination	[1]
166	IPITREEKPAVTAAP	acetylation	[4]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92.
 Lapko VN, Smith DL, Smith JB.
 Protein Sci. 2001 Jun;10(6):1130-6. [PMID: 11369851]
 [3] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738]
 [4] Acetylation of αA-crystallin in the human lens: effects on structure and chaperone function.
 Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A.
 Biochim Biophys Acta. 2012 Feb;1822(2):120-9. [PMID: 22120592] 

Functional Description

 May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. 

Sequence Annotation

 METAL 104 104 Zinc.
 METAL 111 111 Zinc.
 METAL 119 119 Zinc.
 MOD_RES 1 1 N-acetylmethionine (Probable).
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 92 92 N6-acetyllysine; partial.
 MOD_RES 166 166 N6-acetyllysine.
 CARBOHYD 170 170 O-linked (GlcNAc) (By similarity).  

Keyword

 3D-structure; Acetylation; Cataract; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Eye lens protein; Glycoprotein; Metal-binding; Myofibrillar myopathy; Nucleus; Oxidation; Phosphoprotein; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0032432; C:actin filament bundle; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0007568; P:aging; IEA:Compara.
 GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0031109; P:microtubule polymerization or depolymerization; IEA:Compara.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:HGNC.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0032387; P:negative regulation of intracellular transport; IDA:HGNC.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0006457; P:protein folding; NAS:ProtInc.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0051403; P:stress-activated MAPK cascade; IEA:Compara.
 GO:0007021; P:tubulin complex assembly; IEA:Compara. 

Interpro

 IPR002068; a-crystallin/Hsp20_dom.
 IPR001436; Alpha-crystallin/HSP.
 IPR012273; Alpha-crystallin_B.
 IPR003090; Alpha-crystallin_N.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF00525; Crystallin
 PF00011; HSP20 

SMART

  

PROSITE

 PS01031; HSP20 

PRINTS

 PR00299; ACRYSTALLIN.