CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008352
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase kinase/phosphatase 
Protein Synonyms/Alias
 IDH kinase/phosphatase; IDHK/P 
Gene Name
 aceK 
Gene Synonyms/Alias
 STM4185 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
205NELFYRNKAAWLVGKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity). 
Sequence Annotation
 NP_BIND 315 321 ATP (By similarity).
 ACT_SITE 371 371 By similarity.
 BINDING 336 336 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Glyoxylate bypass; Hydrolase; Kinase; Nucleotide-binding; Protein phosphatase; Reference proteome; Serine/threonine-protein kinase; Transferase; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 583 AA 
Protein Sequence
MPRGLELLIA QTILQGFDAQ YGRFLEVTSG AQQRFEQADW HAVQQAMKSR IHLYDHHVGL 60
VVEQLRCITD GKSTDADFLL RVKEHYTRLL PDYPRFEIAE SFFNSVYCRL FDHRSLTPER 120
LFIFSSQPER RFRTIPRPLA KDFFPDHGWE PLLMRILSDL PLRLPWQNKS RDIRYIIAHL 180
TETLGEDALP RCHVQVANEL FYRNKAAWLV GKLTTPDGTL PFLLPIHRTD EGELFVDTCL 240
TTTAEASIVF GFARSYFMVY APLPAALVEW LREILPGKTT AELYMAIGCQ KHAKTESYRE 300
YLCYLAESDE KFIEAPGIRG MVMLVFTLPG FDRVFKIIKD KFAPQKEMSA AHVRACYQLV 360
KEHDRVGRMA DTQEFENFVL DKRQIDPALM ALLRQEAPEK ITDLGEHIVI RHLYIERRMV 420
PLNIWLEQVE GQQLRDAIEE YGNAIRQLAA ANIFPGDMLF KNFGVTRHGR VVFYDYDEIC 480
YMTEVNFRDI PPARYPEDEL ASEPWYSVSP GDVFPEEFRH WLCADPRIGP LFEEMHADLF 540
RADYWRALQT RIKEGHVEDV YAYRRRQRFS VRYGAISSTA NSS 583 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008772; F:[isocitrate dehydrogenase (NADP+)] kinase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0016311; P:dephosphorylation; IEA:GOC.
 GO:0006006; P:glucose metabolic process; IEA:InterPro.
 GO:0006097; P:glyoxylate cycle; IEA:HAMAP.
 GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP. 
Interpro
 IPR010452; Isocitrate_DH_AceK. 
Pfam
 PF06315; AceK 
SMART
  
PROSITE
  
PRINTS