UniProt Accession

 ARA1_YEAST; P38115; D6VQE4 

Genbank Protein ID

 M95580; Z36018; BK006936 

Genbank Nucleotide ID

 AAA35037.1; CAA85107.1; DAA07264.1 

Protein Name

 D-arabinose dehydrogenase [NAD(P)+] heavy chain 

Protein Synonyms/Alias

 AKR3C 

Gene Name

 ARA1 

Gene Synonyms/Alias

 YBR149W; YBR1127 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
46	GTANPHEKLAETKQA	acetylation	[1]
150	KGISGLVKTPVDDSG	acetylation	[1]
150	KGISGLVKTPVDDSG	ubiquitination	[2]
158	TPVDDSGKTMYAADG	ubiquitination	[2]
315	ELNDFGEKYPVRFID	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the oxidation of D-arabinose, L-xylose, L- fucose and L-galactose in the presence of NADP(+). 

Sequence Annotation

 NP_BIND 241 295 NADP (By similarity).
 ACT_SITE 71 71 Proton donor (By similarity).
 BINDING 131 131 Substrate (By similarity).
 MOD_RES 151 151 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; ISS:SGD.
 GO:0045290; F:D-arabinose 1-dehydrogenase [NAD(P)+] activity; IDA:SGD.
 GO:0044262; P:cellular carbohydrate metabolic process; IDA:SGD. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.