| Tag | Content |
|---|
| CPLM ID | CPLM-017784 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ADP-ribosylation factor-binding protein GGA1 |
Protein Synonyms/Alias | Gamma-adaptin-related protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1 |
Gene Name | Gga1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 101 | LIKVVSPKYLGSRTS | ubiquitination | [1] | | 174 | VIFEDEEKSKMLARL | ubiquitination | [1] | | 183 | KMLARLLKSSHPEDL | ubiquitination | [1] | | 198 | RAANKLIKEMVQEDQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity). |
Sequence Annotation | DOMAIN 17 147 VHS.
DOMAIN 171 298 GAT.
DOMAIN 506 627 GAE.
REGION 114 273 Interaction with ARF3 (By similarity).
REGION 299 505 Unstructured hinge.
MOTIF 357 361 Autoinhibitory (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | Acetylation; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 635 AA |
Protein Sequence | MEPAMEPETL EARINRATNP LNKELNWASI NSFCEQLNED FEGPPLATRL LAHKIQSPQE 60
WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKSKILELLY 120
SWTVCLPEEV KIAEAYQMLK KQGIVKSDPK LPEDAIFPLP PPRPKNVIFE DEEKSKMLAR 180
LLKSSHPEDL RAANKLIKEM VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGAA 240
SSSSEDLMKE LYQRCERMRP TLFRLASDTE DNDEALAEIL QANDNLTQVI NLYKQLVRGE 300
EVNGDATASS IPGSTSALLD LSGLDLPPPG TTQPATPTRP GNQSSPEQLS ASVSLLDDEL 360
MSLGLSDPTP PSGTSSDSVG WDNFQSSDGT ESSVPPPAQA PSMDCRPPAQ APPPTSSGLD 420
DLDLLGKTLM QQALPPEAQQ VRWEKQQPAP RLTLRDLQSK SSSPSPGAAS LLHTTSPEPP 480
GPPPQATPTE FSLTSITVPL ESIKPSSILP VTVYDQHGFR VLFHFARDPL PGRSDVLVVV 540
VSMLSTAPQP IRNIVFQSAV PKVMKVRLQP PSGTELPAFN PIVHPSAITQ VLLLANPQKE 600
KVRLRYKLIF TMGDQTYNEM GDVDQFPPPE TWGSL 635 |
Gene Ontology | GO:0030131; C:clathrin adaptor complex; IEA:InterPro. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0045732; P:positive regulation of protein catabolic process; IGI:MGI. GO:0016192; P:vesicle-mediated transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |