UniProt Accession

 COX11_HUMAN; Q9Y6N1; D3DTY5; I3L220; Q6FHB7; Q9BRX0; Q9UME8 

Genbank Protein ID

 AF044321; CR541837; AC007485; AC090824; CH471109; CH471109; BC005895; BI600359; U79270 

Genbank Nucleotide ID

 AAD08645.1; CAG46636.1; EAW94548.1; EAW94550.1; AAH05895.1; AAB50214.1 

Protein Name

 Cytochrome c oxidase assembly protein COX11, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 COX11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	LRWLGTWKRCSLRAR	ubiquitination	[1]
138	VAGHASDKIENMVPV	ubiquitination	[1]
146	IENMVPVKDRIIKIS	ubiquitination	[1]
188	ALAFYRAKNPTDKPV	ubiquitination	[1]
265	SYTFFEAKEGHKLPV	ubiquitination	[1]
269	FEAKEGHKLPVPGYN	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Copper; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 276 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; TAS:ProtInc.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0008535; P:respiratory chain complex IV assembly; TAS:ProtInc.
 GO:0007585; P:respiratory gaseous exchange; TAS:ProtInc. 

Interpro

 IPR023471; CtaG/Cox11_dom.
 IPR007533; Cyt_c_oxidase_assmbl_CtaG. 

Pfam

 PF04442; CtaG_Cox11 

SMART

  

PROSITE

  

PRINTS