| Tag | Content |
|---|
| CPLM ID | CPLM-014723 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metalloreductase STEAP4 |
Protein Synonyms/Alias | Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9 |
Gene Name | STEAP4 |
Gene Synonyms/Alias | STAMP2; TNFAIP9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 332 | TVTQAILKKENPFST | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. |
Sequence Annotation | DOMAIN 247 395 Ferric oxidoreductase.
METAL 304 304 Iron (heme axial ligand) (By similarity).
METAL 397 397 Iron (heme axial ligand) (By similarity).
CARBOHYD 323 323 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Copper; FAD; Flavoprotein; Glycoprotein; Golgi apparatus; Ion transport; Iron; Iron transport; Membrane; Metal-binding; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 459 AA |
Protein Sequence | MEKTCIDALP LTMNSSEKQE TVCIFGTGDF GRSLGLKMLQ CGYSVVFGSR NPQKTTLLPS 60
GAEVLSYSEA AKKSGIIIIA IHREHYDFLT ELTEVLNGKI LVDISNNLKI NQYPESNAEY 120
LAHLVPGAHV VKAFNTISAW ALQSGALDAS RQVFVCGNDS KAKQRVMDIV RNLGLTPMDQ 180
GSLMAAKEIE KYPLQLFPMW RFPFYLSAVL CVFLFFYCVI RDVIYPYVYE KKDNTFRMAI 240
SIPNRIFPIT ALTLLALVYL PGVIAAILQL YRGTKYRRFP DWLDHWMLCR KQLGLVALGF 300
AFLHVLYTLV IPIRYYVRWR LGNLTVTQAI LKKENPFSTS SAWLSDSYVA LGILGFFLFV 360
LLGITSLPSV SNAVNWREFR FVQSKLGYLT LILCTAHTLV YGGKRFLSPS NLRWYLPAAY 420
VLGLIIPCTV LVIKFVLIMP CVDNTLTRIR QGWERNSKH 459 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0045444; P:fat cell differentiation; ISS:UniProtKB. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
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PRINTS | |