CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016287
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipolysis-stimulated lipoprotein receptor 
Protein Synonyms/Alias
  
Gene Name
 LSR 
Gene Synonyms/Alias
 LISCH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
142TVRVVATKQGNAVTLubiquitination[1]
298YAHLSPAKTPPPPAMubiquitination[1]
352RVLYYMEKELANFDPubiquitination[1]
550EERRRPHKEEEEEAYubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). 
Sequence Annotation
 DOMAIN 86 234 Ig-like V-type.
 MOD_RES 185 185 Phosphothreonine (By similarity).
 MOD_RES 364 364 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 493 493 Phosphoserine.
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 530 530 Phosphoserine.
 MOD_RES 535 535 Phosphotyrosine (By similarity).
 MOD_RES 540 540 Phosphoserine.
 MOD_RES 646 646 Phosphoserine (By similarity).
 DISULFID 111 218 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Chylomicron; Complete proteome; Disulfide bond; Immunoglobulin domain; LDL; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix; VLDL. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 649 AA 
Protein Sequence
MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA LAIQVTVSNP 60
YHVVILFQPV TLPCTYQMTS TPTQPIVIWK YKSFCRDRIA DAFSPASVDN QLNAQLAAGN 120
PGYNPYVECQ DSVRTVRVVA TKQGNAVTLG DYYQGRRITI TGNADLTFDQ TAWGDSGVYY 180
CSVVSAQDLQ GNNEAYAELI VLGRTSGVAE LLPGFQAGPI EDWLFVVVVC LAAFLIFLLL 240
GICWCQCCPH TCCCYVRCPC CPDKCCCPEA LYAAGKAATS GVPSIYAPST YAHLSPAKTP 300
PPPAMIPMGP AYNGYPGGYP GDVDRSSSVR SGYRIQASQQ DDSMRVLYYM EKELANFDPS 360
RPGPPSGRVE RAMSEVTSLH EDDWRSRPSR GPALTPIRDE EWGGHSPRSP RGWDQEPARE 420
QAGGGWRARR PRARSVDALD DLTPPSTAES GSRSPTSNGG RSRAYMPPRS RSRDDLYDQD 480
DSRDFPRSRD PHYDDFRSRE RPPADPRSHH HRTRDPRDNG SRSGDLPYDG RLLEEAVRKK 540
GSEERRRPHK EEEEEAYYPP APPPYSETDS QASRERRLKK NLALSRESLV V 591 
Gene Ontology
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:HGNC.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0009790; P:embryo development; ISS:HGNC.
 GO:0001889; P:liver development; ISS:HGNC.
 GO:0019216; P:regulation of lipid metabolic process; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR008664; LISCH7. 
Pfam
 PF05624; LSR 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS