UniProt Accession

 HNS_SALTY; P0A1S2; P17428 

Genbank Protein ID

 M37891; X14375; AE006468 

Genbank Nucleotide ID

 AAB61148.1; CAA32549.1; AAL20669.1 

Protein Name

 DNA-binding protein H-NS 

Protein Synonyms/Alias

 Histone-like protein HLP-II; Protein B1; Protein H1 

Gene Name

 hns 

Gene Synonyms/Alias

 hnsA; osmZ; STM1751 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
57	EVEERTRKLQQYREM	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR027444; H-NS_C_dom.
 IPR001801; Histone_HNS.
 IPR027454; Histone_HNS_oligo_dom. 

Pfam

 PF00816; Histone_HNS 

SMART

 SM00528; HNS 

PROSITE

  

PRINTS