CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031492
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat and LEM domain-containing protein 1 
Protein Synonyms/Alias
 cDNA FLJ53264, highly similar to Ankyrin repeat domain-containing protein 41 
Gene Name
 ANKLE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
422VSDLELLKGLRALGRubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MWTPVRRGAA WLGTLLGPGE GPPEPRGGAA HAHKPPAGSR KSTDQAVRFG PSQGMCSEAR 60
LARRLRDALR EEEPWAVEEL LRCGADPNLV LEDGAAAVHL AAGARHPRGL RCLGALLRQG 120
GDPNARSVEA LTPLHVAAAW GCRRGLELLL SQGADPALRD QDGLRPLDLA LQQGHLECAR 180
VLQDLDTRTR TRTRIGAETQ EPEPAPGTPG LSGPTDETLD SIALQKQPCR GDNRDIGLEA 240
DPGPPSLPVP LETVDKHGSS ASPPGHWDYS SDASFVTAVE VSGAEDPASD TPPWAGSLPP 300
TRQGLLHVVH ANQRVPRSQG TEAELNARLQ ALTLTPPNAA GFQSSPSSMP LLDRSPAHSP 360
PRTPTPGASD CHCLWEHQTS IDSDMATLWL TEDEASSTGG REPVGPCRHL PVSTVSDLEL 420
LKGLRALGRL RTCQPEPSH 439 
Gene Ontology
  
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS