CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041589
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-Coenzyme A dehydrogenase, medium chain 
Protein Synonyms/Alias
 Medium-chain-specific acyl-CoA dehydrogenase, mitochondrial 
Gene Name
 Acadm 
Gene Synonyms/Alias
 rCG_28992 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
54EFQTIARKFAREEIIacetylation[1]
69PVAPDYDKSGEYPFPacetylation[1]
79EYPFPLIKRAWELGLacetylation[1]
178GIKTKAEKKGDEYVIacetylation[1]
217DPKVPASKAFTGFIVacetylation[1]
235TPGIHIGKKELNMGQacetylation[1]
259FEDVRVPKENVLIGEacetylation[1]
301RALDEATKYALDRKTacetylation[1]
307TKYALDRKTFGKLLVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 421 AA 
Protein Sequence
MAAALRRGYK VLRSVSHFEC RAQHTKPSLK QEPGLGFSFE LTEQQKEFQT IARKFAREEI 60
IPVAPDYDKS GEYPFPLIKR AWELGLINTH IPESCGGLGL GTFDACLITE ELAYGCTGVQ 120
TAIEANSLGQ MPVIIAGNDQ QKKKYLGRMT EQLMMCAYCV TEPSAGSDVA GIKTKAEKKG 180
DEYVINGQKM WITNGGKANW YFVLTRSNPD PKVPASKAFT GFIVEADTPG IHIGKKELNM 240
GQRCSDTRGI TFEDVRVPKE NVLIGEGAGF KIAMGAFDRT RPTVAAGAVG LAQRALDEAT 300
KYALDRKTFG KLLVEHQGVS FLLAEMAMKV ELARLSYQRA AWEVDSGRRN TYFASIAKAF 360
AGDIANQLAT DAVQIFGGYG FNTEYPVEKL MRDAKIYQIY EGTAQIQRLI IAREHIEKYK 420
N 421 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0070991; F:medium-chain-acyl-CoA dehydrogenase activity; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0045329; P:carnitine biosynthetic process; IEA:Compara.
 GO:0019254; P:carnitine metabolic process, CoA-linked; IEA:Compara.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Compara.
 GO:0005978; P:glycogen biosynthetic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0051793; P:medium-chain fatty acid catabolic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006111; P:regulation of gluconeogenesis; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 
PRINTS