| Tag | Content |
|---|
| CPLM ID | CPLM-018212 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Urea transporter 1 |
Protein Synonyms/Alias | Solute carrier family 14 member 1; Urea transporter B; UT-B; Urea transporter, erythrocyte |
Gene Name | Slc14a1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 417 | IYRMPLSKVTYSEEN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Low-affinity facilitative urea transporter that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. the rate of urea conduction is increased by hypoosmotic stress (By similarity). Mediates urea transport in erythrocytes. |
Sequence Annotation | CARBOHYD 206 206 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 384 AA |
Protein Sequence | MNGQSLTGGT DDAHHGPLWI DPFGNRGDKA APEGFRRLSL ALAQRWREQE PEEEIAMEDS 60
PTMVKVDRGE NQILSCRGRR CGFKVLGYVT GDMKEFANWL KDKPVVLQFM DWILRGISQV 120
VFVSNPISGI LILVGLLVQN PWWALCGCVG TVVSTLTALL LSQDRSAIAA GLQGYNATLV 180
GILMAVFSNK GDYFWWLIFP VSAMSMTCPV FSSALSSVLS KWDLPVFTLP FNMALSMYLS 240
ATGHYNTFFP SKLFTPVSSV PNITWSELSA LELLKSLPVG VGQIYGCDNP WTGGIFLCAI 300
LLSSPLMCLH AAIGSLLGVI AGLSLAAPFE DIYFGLWGFN SSLACIAIGG MFMALTWQTH 360
LLALACALFT AYFGACMAHL MAVVHLPACT WSFCLATLLF LLLTTKNPNI YRMPLSKVTY 420
SEENRIFYLQ NKKRMVESPL 440 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; TAS:MGI. GO:0005886; C:plasma membrane; IDA:MGI. GO:0015204; F:urea transmembrane transporter activity; IMP:MGI. GO:0005372; F:water transmembrane transporter activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |